{"id":"W2563316121","doi":"10.1021/acschembio.6b01037","title":"Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; U.S. Department of Defense","keywords":"Chagas disease; Drug; Drug discovery; Yeast; Drug target; Computational biology; Disease; Biology; Trypanosoma cruzi; Drug development; Pharmacology; Virology; Medicine; Genetics; Bioinformatics; Computer science; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000435956,0.0005056715,0.0005449114,0.000343416,0.0001651917,0.0004846555,0.0003142926,0.0002702678,0.0006093648],"category_scores_gemma":[0.0004813512,0.0002197067,0.0003225167,0.0004579033,0.0002652821,0.0001772259,0.0003879668,0.0006231273,0.0002230464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000324832,"about_ca_system_score_gemma":0.0002647112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009080873,"about_ca_topic_score_gemma":0.001562243,"domain_scores_codex":[0.99983,0.00004703013,0.00001797461,0.00003041937,0.00005913466,0.00001538386],"domain_scores_gemma":[0.9998833,0.00004536753,0.000028627,0.00001531517,0.00001452879,0.00001282184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002289096,0.0001026497,0.001185984,0.0001459523,0.0000457893,0.0001511029,0.00005721288,0.00668078,0.967422,0.001177851,0.0001419848,0.02265975],"study_design_scores_gemma":[0.0001638799,0.001232406,0.00295959,0.00002437772,0.00009179873,0.0005935997,0.00008334824,0.03676995,0.9475973,0.0005263422,0.009926203,0.00003116374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9123332,0.002709866,0.07985044,0.0003210134,0.00004621063,0.0004049756,0.0008087198,0.0008216182,0.002703994],"genre_scores_gemma":[0.8849243,0.003763705,0.1084988,0.0001423666,0.00001085477,0.0002313508,0.0009924549,0.0001079179,0.00132824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009080873,"threshold_uncertainty_score":0.002356827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767535801107238,"score_gpt":0.2883984393136665,"score_spread":0.2707230813025941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}