{"id":"W2563316121","doi":"10.1021/acschembio.6b01037","title":"Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; U.S. Department of Defense","keywords":"Chagas disease; Drug; Drug discovery; Yeast; Drug target; Computational biology; Disease; Biology; Trypanosoma cruzi; Drug development; Pharmacology; Virology; Medicine; Genetics; Bioinformatics; Computer science; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000325975,0.0001302111,0.0002410402,0.0001173067,0.00003842294,0.00000744021,0.00009469411,0.0000840649,0.00007487387],"category_scores_gemma":[0.000851576,0.00008613936,0.00007075856,0.0002575389,0.00029967,0.0001198683,0.0001106194,0.0001595212,0.00007088252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003016646,"about_ca_system_score_gemma":0.0001689027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001199596,"about_ca_topic_score_gemma":0.000009565518,"domain_scores_codex":[0.9988058,0.00008689685,0.0002171111,0.0003575861,0.0001069648,0.0004255935],"domain_scores_gemma":[0.9991558,0.0001525812,0.00004754471,0.0002908394,0.0000920879,0.0002611248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003528995,0.0001409623,0.01109191,0.00001063633,0.00002192689,0.00001416816,0.00002449409,5.909535e-8,0.9845678,0.0008964238,0.001187757,0.001691013],"study_design_scores_gemma":[0.002476996,0.00004930265,0.4482709,0.0001540602,0.00003331071,0.00003517155,0.0001111602,0.0001019369,0.541476,0.002136463,0.004887103,0.0002677176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925247,0.0002850647,0.0003456123,0.005778074,0.00006489242,0.0002799732,0.0002231056,0.00006814414,0.0004304147],"genre_scores_gemma":[0.9983826,0.0001084718,0.0003323471,0.0001908247,0.0002384268,0.00002913435,0.0001869464,0.00001455588,0.000516701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4430918,"threshold_uncertainty_score":0.3512661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767535801107238,"score_gpt":0.2883984393136665,"score_spread":0.2707230813025941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}