{"id":"W2563345922","doi":"10.1182/blood.v126.23.3120.3120","title":"Population Pharmacokinetics of Fludarabine and Treosulfan in Patients with Thalassemia Undergoing Hematopoietic Stem Cell Transplantation","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Treosulfan; Fludarabine; Medicine; ThioTEPA; Busulfan; Pharmacokinetics; Transplantation; Hematopoietic stem cell transplantation; Population; Internal medicine; Regimen; Oncology; Pharmacology; Cyclophosphamide; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150327,0.0001005854,0.0002044252,0.0001280243,0.00001246035,0.000006577221,0.00003770186,0.00005340642,0.000004896975],"category_scores_gemma":[0.00001188155,0.00008032805,0.00001385388,0.0001974207,0.00003076494,0.00007864686,0.00001262498,0.00008919738,0.000002016165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009840399,"about_ca_system_score_gemma":0.0001604404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004724519,"about_ca_topic_score_gemma":0.00001845979,"domain_scores_codex":[0.9990289,0.00003857082,0.0002247981,0.0001603063,0.0003919521,0.0001554463],"domain_scores_gemma":[0.999528,0.00007454314,0.00007248888,0.0001128976,0.00009436993,0.0001176979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006816626,0.000608378,0.9943946,0.0006707449,0.00003106516,0.0000403265,0.00111912,0.0000686414,0.001783431,0.00001624852,0.00002881171,0.0005569664],"study_design_scores_gemma":[0.0479181,0.001209426,0.9178391,0.0004014122,0.0003410398,0.00004931614,0.0002757006,0.0006939483,0.03109307,0.00003320036,0.000005484864,0.0001402472],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987965,0.00008705338,0.0001813491,0.00004810917,0.00001784679,0.0003389748,0.000007860809,0.00001564365,0.0005066565],"genre_scores_gemma":[0.9991404,0.00003444221,0.0006293227,0.00001619788,0.00001763993,0.000006318051,0.00006987815,0.00001916955,0.00006667026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07655555,"threshold_uncertainty_score":0.3275683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215959914491593,"score_gpt":0.2483027451657921,"score_spread":0.2361431460208761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}