{"id":"W2563378033","doi":"10.1016/s1525-0016(16)34107-7","title":"498. Optimization of rAAV Targets ON Bipolar Cells and Rescues the nobnyx Mouse Model of X-Linked Congenital Stationary Night Blindness","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"Retina; Retinal; Biology; Transduction (biophysics); Transgene; Erg; Cell biology; Electroretinography; Retinal degeneration; Molecular biology; Genetics; Neuroscience; Gene; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000311355,0.000613939,0.0003038316,0.0005425603,0.0002675991,0.0004717881,0.0005340663,0.0005411503,0.003589169],"category_scores_gemma":[0.0001171638,0.0002662537,0.0004024336,0.0001872501,0.0002985454,0.0001688798,0.0002441711,0.000678141,0.001638895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005029818,"about_ca_system_score_gemma":0.0003788305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002176459,"about_ca_topic_score_gemma":0.003444869,"domain_scores_codex":[0.9995497,0.00006116759,0.00005236124,0.00009456598,0.000156179,0.00008600531],"domain_scores_gemma":[0.9998088,0.00002038129,0.00006762031,0.00001896105,0.00002493757,0.00005929475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006119754,0.00008058855,0.00009641361,0.00002440868,0.000003418544,0.00003920039,0.00001652208,0.0001235029,0.9977064,0.0002466426,0.00007436161,0.001527194],"study_design_scores_gemma":[0.00005578749,0.0006343028,0.002473371,0.00002302426,0.00001969061,0.0002918042,0.00004588324,0.001916818,0.9825283,0.00006707189,0.01193334,0.00001060323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963084,0.001015849,0.01961602,0.0002634807,0.0001356219,0.0007043522,0.003096072,0.0003776167,0.01170702],"genre_scores_gemma":[0.9273564,0.00138296,0.02993047,0.0001355322,0.00002568514,0.0007222312,0.003715778,0.0003633857,0.03636756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003589169,"threshold_uncertainty_score":0.012007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811396924404248,"score_gpt":0.2395704905037637,"score_spread":0.2214565212597212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}