{"id":"W2563413435","doi":"10.1158/1538-7445.am2015-496","title":"Abstract 496: Checkpoint kinase 1 inhibition suppresses cell growth and enhances cisplatin sensitivity in medulloblastoma cells","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"CHEK1; Medulloblastoma; Cancer research; Biology; Cisplatin; Cell cycle; Viability assay; Cell growth; Mitotic catastrophe; Apoptosis; Cell cycle checkpoint; Chemotherapy; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008619351,0.0003602241,0.0004260673,0.0003327743,0.0001973449,0.000206897,0.0002145763,0.000218267,0.00284875],"category_scores_gemma":[0.0000831585,0.0001066519,0.0002651936,0.0003014409,0.0001510215,0.0001423748,0.0001437259,0.0006270898,0.0006034099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003260955,"about_ca_system_score_gemma":0.0003152637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009932119,"about_ca_topic_score_gemma":0.001346603,"domain_scores_codex":[0.9998715,0.00001345345,0.00001622926,0.00002676523,0.00004648228,0.00002552553],"domain_scores_gemma":[0.9999617,0.000007166369,0.000008287439,0.000005711599,0.000006696105,0.00001039547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003703256,0.0001246145,0.0003339832,0.0001305848,0.00001545775,0.00005298567,0.00001909484,0.0001503062,0.9949151,0.00006152773,0.0004258714,0.003400225],"study_design_scores_gemma":[0.00006213368,0.0007382148,0.005941163,0.00001013582,0.00002622507,0.0001918527,0.00002700786,0.00113579,0.9874385,0.00003467054,0.004388567,0.000005713641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887924,0.003627825,0.001782335,0.0002072748,0.00012809,0.00009161802,0.002231286,0.0002613332,0.002877883],"genre_scores_gemma":[0.9859108,0.002660852,0.002356644,0.00009474323,0.00002648441,0.0001437633,0.003711711,0.00003469778,0.005060382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00284875,"threshold_uncertainty_score":0.009530008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06240447642858538,"score_gpt":0.3667262942519792,"score_spread":0.3043218178233938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}