{"id":"W2563442740","doi":"10.1038/ng.3745","title":"Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease","year":2016,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":382,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto Western Hospital; Hospital for Sick Children; University of Calgary","funders":"National Institute on Aging; NIHR Cambridge Biomedical Research Centre; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; NIHR BioResource; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; Center for Individualized Medicine, Mayo Clinic; British Heart Foundation; Exzellenzclusters Entzündungsforschung; National Institute for Health and Care Research; Ministerio de Ciencia e Innovación; Kwanjeong Educational Foundation; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; NHS Blood and Transplant; Genome Canada","keywords":"Primary sclerosing cholangitis; Inflammatory bowel disease; Biology; Genome-wide association study; Allele; Locus (genetics); Ulcerative colitis; Genetics; Single-nucleotide polymorphism; SNP; Disease; Genetic association; Gastroenterology; Internal medicine; Genotype; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028833,0.0005639983,0.0006048299,0.001535598,0.0005099684,0.0007716921,0.0004109741,0.0008379255,0.001866241],"category_scores_gemma":[0.002740229,0.0004308792,0.0009076336,0.001733158,0.000618395,0.0002656494,0.0005290239,0.001033127,0.0002077078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001775771,"about_ca_system_score_gemma":0.0002403727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001952834,"about_ca_topic_score_gemma":0.003351801,"domain_scores_codex":[0.9987963,0.0005564317,0.0001040481,0.0002737927,0.0001589908,0.0001103535],"domain_scores_gemma":[0.9977106,0.001152135,0.0005525053,0.0002665744,0.0001247877,0.0001934992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001223228,0.00009450581,0.9716287,0.00004287874,0.001269452,0.0005039784,0.0001083757,0.0002654776,0.01811862,0.0002185868,0.0002819978,0.006244026],"study_design_scores_gemma":[0.00003693295,0.0001021721,0.9966583,0.000007575608,0.0004768693,0.0006430927,0.00007013127,0.0005888027,0.0008869137,0.0002655751,0.0002555753,0.000008079813],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969999,0.0009508876,0.0008377428,0.0002500002,0.00002720265,0.000004304552,0.0002346061,0.00002465428,0.000670573],"genre_scores_gemma":[0.9988207,0.0002469578,0.0005187585,0.00005540283,0.00003627355,0.000003695462,0.0001250623,0.000009589248,0.0001834731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001952834,"threshold_uncertainty_score":0.006243229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314106115463116,"score_gpt":0.235213360899419,"score_spread":0.2220722997447879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}