{"id":"W2563442740","doi":"10.1038/ng.3745","title":"Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease","year":2016,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":382,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto Western Hospital; Hospital for Sick Children; University of Calgary","funders":"National Institute on Aging; NIHR Cambridge Biomedical Research Centre; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; NIHR BioResource; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; Center for Individualized Medicine, Mayo Clinic; British Heart Foundation; Exzellenzclusters Entzündungsforschung; National Institute for Health and Care Research; Ministerio de Ciencia e Innovación; Kwanjeong Educational Foundation; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; NHS Blood and Transplant; Genome Canada","keywords":"Primary sclerosing cholangitis; Inflammatory bowel disease; Biology; Genome-wide association study; Allele; Locus (genetics); Ulcerative colitis; Genetics; Single-nucleotide polymorphism; SNP; Disease; Genetic association; Gastroenterology; Internal medicine; Genotype; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242492,0.0001369095,0.0001731004,0.00006924406,0.0002057293,0.00004510564,0.0001087891,0.0001223764,0.00001451445],"category_scores_gemma":[0.0005032641,0.00007844761,0.00005009419,0.0001254039,0.00008324315,0.00008642894,0.00007807314,0.0003182169,0.000003832869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009932845,"about_ca_system_score_gemma":0.0001789359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000543865,"about_ca_topic_score_gemma":0.00006062529,"domain_scores_codex":[0.998812,0.000156491,0.0002432454,0.0002014836,0.0004258027,0.0001609529],"domain_scores_gemma":[0.9985797,0.0003919053,0.0002550857,0.0004346168,0.0001972932,0.0001413489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001701306,0.0001052899,0.9968823,0.00008262174,0.000153251,0.000005601083,0.000968896,0.00001660774,0.0005002588,0.000003274199,0.0002884537,0.0008233789],"study_design_scores_gemma":[0.001608,0.0001912962,0.9961855,0.0001092907,0.0007296117,0.00000125183,0.0004613172,0.000007088439,0.0001179014,0.0002584427,0.000220887,0.0001094052],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869055,0.01170304,0.00007196607,0.000565758,0.00008402521,0.0005693295,0.00003775335,0.00002582057,0.00003681373],"genre_scores_gemma":[0.9974135,0.001314279,0.000150202,0.000156524,0.0001444302,0.000007799965,0.00001463843,0.00002268255,0.0007759907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01050796,"threshold_uncertainty_score":0.3199001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314106115463116,"score_gpt":0.235213360899419,"score_spread":0.2220722997447879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}