{"id":"W2563443673","doi":"10.1128/mbio.01733-16","title":"The Ruler Protein EscP of the Enteropathogenic <i>Escherichia coli</i> Type III Secretion System Is Involved in Calcium Sensing and Secretion Hierarchy Regulation by Interacting with the Gatekeeper Protein SepL","year":2017,"lang":"en","type":"article","venue":"mBio","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Ben-Gurion University of the Negev; Israel Science Foundation; Government of Canada","keywords":"Secretion; Effector; Virulence; Type three secretion system; Biology; Microbiology; Cell biology; Escherichia coli; Bacteria; Pathogenic bacteria; Secretory protein; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006999134,0.0001563811,0.0001440413,0.00001607698,0.000690426,0.0001277778,0.0002628395,0.0001002769,0.00000121396],"category_scores_gemma":[0.0001995399,0.00008388025,0.00004568768,0.00009399967,0.0003358749,0.00001696623,0.000313848,0.0002362712,7.507589e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005162618,"about_ca_system_score_gemma":0.00007246779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003670888,"about_ca_topic_score_gemma":0.0007283853,"domain_scores_codex":[0.9986878,0.0003434542,0.0002139422,0.0002822335,0.0002299674,0.000242627],"domain_scores_gemma":[0.9988671,0.00002745426,0.000297891,0.0005819639,0.0001921878,0.00003343522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003293884,0.00001260046,0.002633633,0.00006822102,0.00004499492,7.025351e-7,0.0004072743,0.000003535816,0.9957399,0.00002752688,0.0001740048,0.0005581866],"study_design_scores_gemma":[0.00114889,0.0003665924,0.0179571,0.000659147,0.00003248713,0.000007122181,0.001803106,0.005997986,0.9669679,0.00003330384,0.004780035,0.0002462728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964263,0.0003849526,0.0002794225,0.001407642,0.0000689791,0.00117941,0.000007636816,0.000007860565,0.0002377476],"genre_scores_gemma":[0.9989406,0.00002727499,0.0001057459,0.00006423102,0.0000671349,0.00006816437,0.00001305464,0.00002156537,0.0006921723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02877197,"threshold_uncertainty_score":0.5310268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159824499306042,"score_gpt":0.2481154210545483,"score_spread":0.2365171760614879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}