{"id":"W2563443673","doi":"10.1128/mbio.01733-16","title":"The Ruler Protein EscP of the Enteropathogenic <i>Escherichia coli</i> Type III Secretion System Is Involved in Calcium Sensing and Secretion Hierarchy Regulation by Interacting with the Gatekeeper Protein SepL","year":2017,"lang":"en","type":"article","venue":"mBio","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Ben-Gurion University of the Negev; Israel Science Foundation; Government of Canada","keywords":"Secretion; Effector; Virulence; Type three secretion system; Biology; Microbiology; Cell biology; Escherichia coli; Bacteria; Pathogenic bacteria; Secretory protein; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009952253,0.0004532127,0.0003326097,0.0001735974,0.0003069212,0.0004188442,0.0002210763,0.0005382274,0.0008538491],"category_scores_gemma":[0.0001626983,0.0001204455,0.0003907851,0.0001617909,0.0002357781,0.0002778431,0.0004550885,0.0004496025,0.0006339716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003239055,"about_ca_system_score_gemma":0.0002100667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004572719,"about_ca_topic_score_gemma":0.0003314815,"domain_scores_codex":[0.9998639,0.00001768998,0.000009136474,0.00004553813,0.00003882052,0.00002491144],"domain_scores_gemma":[0.999921,0.00001058962,0.00003035429,0.000006668545,0.00001109808,0.00002033313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001149364,0.00001845309,0.001128912,0.00007849423,0.000009899883,0.0004682532,0.00001629937,0.00008930005,0.9947323,0.0001591316,0.000136187,0.003047921],"study_design_scores_gemma":[0.0000198152,0.0001234912,0.01648975,0.00001800736,0.000027096,0.002368204,0.00005237535,0.003242031,0.9696163,0.0001632409,0.00786375,0.00001601534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785048,0.006040429,0.01169158,0.0004831163,0.00009071358,0.00005150135,0.0006615043,0.0002371616,0.002239106],"genre_scores_gemma":[0.9876424,0.00146665,0.006002479,0.0002160033,0.00002011406,0.00002259019,0.001084188,0.00003221814,0.003513369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008538491,"threshold_uncertainty_score":0.002856374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159824499306042,"score_gpt":0.2481154210545483,"score_spread":0.2365171760614879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}