{"id":"W2563445076","doi":"10.1021/acs.molpharmaceut.6b00963","title":"<sup>64</sup>Cu-Labeled Trastuzumab Fab-PEG<sub>24</sub>-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents","year":2017,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Institute of Cancer Research; Ontario Institute for Cancer Research; University of Toronto","keywords":"Biodistribution; Trastuzumab; Chemistry; Pharmacokinetics; Cancer research; In vitro; Pharmacology; Cancer; Medicine; Breast cancer; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008388394,0.0005945203,0.000872847,0.0003345384,0.0005420113,0.0005076224,0.0005566234,0.0001015282,0.00006411213],"category_scores_gemma":[0.0003017164,0.0006494214,0.0001337015,0.0003010521,0.0005174285,0.0001937228,0.0003440677,0.000813455,0.00003665931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006001535,"about_ca_system_score_gemma":0.0001872348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000942554,"about_ca_topic_score_gemma":0.00001020364,"domain_scores_codex":[0.9960183,0.0001829785,0.0008495757,0.001059264,0.000703772,0.001186092],"domain_scores_gemma":[0.997644,0.0001315155,0.000248145,0.0008673467,0.0003409559,0.0007680319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001057898,0.0006772232,0.04957412,0.0006609563,0.0003034524,0.0008459548,0.0008665507,0.0001670125,0.8672678,0.00004270994,0.04319108,0.03534523],"study_design_scores_gemma":[0.01309564,0.0003687428,0.004979635,0.0003128627,0.0003394528,0.0002545378,0.000518729,0.07889264,0.745752,0.0000655308,0.1546423,0.0007779368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772339,0.01151852,0.00221036,0.004676065,0.0003265057,0.003164079,0.000630091,0.00009427625,0.0001461749],"genre_scores_gemma":[0.9942477,0.00274949,0.00104918,0.001015277,0.000161395,0.0002734866,0.0002859525,0.0001384733,0.00007901124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1215158,"threshold_uncertainty_score":0.9995957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0501293980763969,"score_gpt":0.3858409213797706,"score_spread":0.3357115233033737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}