{"id":"W2563445076","doi":"10.1021/acs.molpharmaceut.6b00963","title":"<sup>64</sup>Cu-Labeled Trastuzumab Fab-PEG<sub>24</sub>-EGF Radioimmunoconjugates Bispecific for HER2 and EGFR: Pharmacokinetics, Biodistribution, and Tumor Imaging by PET in Comparison to Monospecific Agents","year":2017,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Institute of Cancer Research; Ontario Institute for Cancer Research; University of Toronto","keywords":"Biodistribution; Trastuzumab; Chemistry; Pharmacokinetics; Cancer research; In vitro; Pharmacology; Cancer; Medicine; Breast cancer; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133548,0.0002763391,0.0001641689,0.0001006845,0.00005244031,0.0001540417,0.0001729188,0.0001567743,0.0004458257],"category_scores_gemma":[0.0001375438,0.0001136113,0.00007489564,0.0001136859,0.0001341285,0.000131537,0.00009979204,0.000190006,0.0001967525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003083383,"about_ca_system_score_gemma":0.000118686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007399631,"about_ca_topic_score_gemma":0.0005387808,"domain_scores_codex":[0.999913,0.00002157441,0.000005116597,0.00001661085,0.00002577184,0.00001794445],"domain_scores_gemma":[0.9999441,0.00000979897,0.00001845056,0.000004838731,0.00001093912,0.00001179111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003372777,0.00001978523,0.0002462479,0.00002208486,0.000005125913,0.00003044956,0.00000740831,0.0002866404,0.9961393,0.00007359176,0.00006280473,0.002769256],"study_design_scores_gemma":[0.00001559853,0.0003708176,0.001725723,0.000001899012,0.00001846529,0.0002295989,0.000006393179,0.001591825,0.9946212,0.0000168514,0.00139865,0.000002926084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935243,0.00126717,0.004086739,0.00004091383,0.00001020189,0.00001953937,0.00007443118,0.00006479427,0.0009117955],"genre_scores_gemma":[0.9924144,0.0006535739,0.004190457,0.00005135131,0.000008711704,0.00003219348,0.0002402058,0.00002623699,0.002382931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007399631,"threshold_uncertainty_score":0.002237141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0501293980763969,"score_gpt":0.3858409213797706,"score_spread":0.3357115233033737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}