{"id":"W2563544267","doi":"10.1016/j.devcel.2016.11.024","title":"Selective Lysosomal Transporter Degradation by Organelle Membrane Fusion","year":2016,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lysosome; Biology; Cell biology; Organelle; Endocytosis; Biochemistry; Catabolism; Membrane transport protein; Transporter; Membrane protein; Transport protein; Membrane; Cell; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006908821,0.0001484442,0.00009371917,0.00002860593,0.00008043182,0.000007739643,0.0000914573,0.0001305141,0.0003446175],"category_scores_gemma":[0.0000025718,0.0001142749,0.00005363963,0.00007233077,0.00003503047,0.000007816237,0.00001443728,0.00003978306,0.00005779287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003324541,"about_ca_system_score_gemma":0.0000584425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001142301,"about_ca_topic_score_gemma":0.00003759822,"domain_scores_codex":[0.9991526,0.00001830389,0.0001793063,0.0003141851,0.0001360275,0.0001995711],"domain_scores_gemma":[0.9997494,0.000003676142,0.00004382713,0.00009314869,0.00003734191,0.00007258658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009420035,0.00005907538,0.00897963,0.00001031953,0.00001434829,0.000002770654,0.00007922644,2.198515e-7,0.9883191,0.000002899472,0.0007581934,0.001680027],"study_design_scores_gemma":[0.0008083735,0.00007441143,0.005306411,0.000008837216,0.00000936548,0.000007188429,0.00003874457,0.000001933297,0.934072,0.000006758098,0.05946128,0.0002047451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748793,0.0001191619,0.02067553,0.00008061375,0.00008963814,0.0001487965,0.00003276241,0.00001998011,0.00395419],"genre_scores_gemma":[0.9869246,0.0001985548,0.0005878062,0.0001045046,0.00004721382,0.00001103341,0.004074329,0.00002350991,0.00802841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05870309,"threshold_uncertainty_score":0.4659994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004837333893379079,"score_gpt":0.1774466007850186,"score_spread":0.1726092668916395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}