{"id":"W2563544267","doi":"10.1016/j.devcel.2016.11.024","title":"Selective Lysosomal Transporter Degradation by Organelle Membrane Fusion","year":2016,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lysosome; Biology; Cell biology; Organelle; Endocytosis; Biochemistry; Catabolism; Membrane transport protein; Transporter; Membrane protein; Transport protein; Membrane; Cell; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003103151,0.0002718709,0.0003615909,0.0002063137,0.0002127465,0.0006978346,0.0002513521,0.0005057703,0.001182531],"category_scores_gemma":[0.000249692,0.000184242,0.0003460818,0.0001726779,0.000282757,0.0005305849,0.0004690891,0.0004897154,0.0004626362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007561744,"about_ca_system_score_gemma":0.0002469768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005162036,"about_ca_topic_score_gemma":0.0005000271,"domain_scores_codex":[0.999745,0.00003917201,0.00002665527,0.00005878004,0.00005535624,0.00007508207],"domain_scores_gemma":[0.9998648,0.00003304554,0.00003276275,0.00003161077,0.00001665176,0.00002109846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001898112,0.00001429291,0.000166789,0.00002737164,0.000009799332,0.0001307511,0.00001557061,0.0001421173,0.9962574,0.00120545,0.000123516,0.001717042],"study_design_scores_gemma":[0.00000692648,0.0000252783,0.0003717076,0.000001476913,0.000005036652,0.000331808,0.00000859751,0.001035226,0.9968272,0.0001085179,0.001274211,0.0000040916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781983,0.002804154,0.01431212,0.0003359692,0.00006833464,0.00003788412,0.0004172756,0.0002912094,0.003534642],"genre_scores_gemma":[0.9953312,0.0004492592,0.001752764,0.00005180509,0.000007740525,0.00001133073,0.0002052318,0.00004059688,0.002150016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182531,"threshold_uncertainty_score":0.005486429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004837333893379079,"score_gpt":0.1774466007850186,"score_spread":0.1726092668916395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}