{"id":"W2563552218","doi":"10.1093/biolreprod/85.s1.654","title":"Either Kras Activation or Pten Loss Similarly Enhance the Mutant CTNNB1-Induced Genetic Program to Promote Granulosa Cell Tumor Development in Ovary and Testis.","year":2011,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cegep de Saint Hyacinthe","funders":"","keywords":"PTEN; Biology; KRAS; Cancer research; Wnt signaling pathway; Granulosa cell; Ovary; Phenotype; Mutation; PI3K/AKT/mTOR pathway; Cell biology; Signal transduction; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957003,0.0001506315,0.0001421079,0.00007519132,0.00006153237,0.00000579246,0.0001071417,0.0001500751,0.000008859218],"category_scores_gemma":[0.0001150345,0.0001116957,0.00002457009,0.0002069341,0.0001013323,0.000007897735,0.00006512344,0.00008711325,0.000002721935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000329267,"about_ca_system_score_gemma":0.0001161147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009399475,"about_ca_topic_score_gemma":0.00009671109,"domain_scores_codex":[0.9987475,0.00007935397,0.0003021981,0.0006084307,0.00007084166,0.0001916978],"domain_scores_gemma":[0.9992668,0.000005353641,0.0001834259,0.0003954169,0.0001125535,0.0000364425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003010981,0.0001130515,0.00341678,0.00001986577,0.00001711765,8.650959e-7,0.0003312713,0.00001553959,0.7814648,0.000001776724,0.00002137488,0.2142964],"study_design_scores_gemma":[0.0002500866,0.0007129365,0.1045526,0.00002314914,0.00001043214,0.00003392437,0.00002854348,0.00001994719,0.887253,0.00005170346,0.006925453,0.000138278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972606,0.000577045,0.000638528,0.0002647308,0.0001609956,0.001033295,0.000002140667,0.00002033458,0.00004234673],"genre_scores_gemma":[0.9924543,0.0000795265,0.006959101,0.00002818225,0.0001401108,0.00017159,0.0000290001,0.00001812775,0.0001200516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2141581,"threshold_uncertainty_score":0.455482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01938334349367163,"score_gpt":0.2609825375603738,"score_spread":0.2415991940667021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}