{"id":"W2563890329","doi":"10.1093/ndt/gfv191.43","title":"SP323EFFECTS OF RVX-208, A FIRST IN CLASS EPIGENETIC BET INHIBITOR, ON KEY RENAL PARAMETERS IN SUBJECTS WITH A HISTORY OF CVD, AND CHRONIC KIDNEY DISEASE (CKD); A POST-HOC ANALYSIS OF PATIENTS FROM THE ASSERT, SUSTAIN AND ASSURE CLINICAL TRIALS","year":2015,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Medicine; Post-hoc analysis; BET inhibitor; Kidney disease; Internal medicine; Disease; Epigenetics; Endocrinology; Bromodomain; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002443699,0.0001590824,0.001068264,0.0005334784,0.00001528719,0.00000330624,0.00006157572,0.0003372295,0.000006006306],"category_scores_gemma":[0.0007661647,0.000104206,0.0001612974,0.0005581265,0.0007833604,0.00004750724,0.000009628023,0.0002727032,1.18988e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001327746,"about_ca_system_score_gemma":0.0006304038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107561,"about_ca_topic_score_gemma":0.009971298,"domain_scores_codex":[0.9966305,0.001448825,0.001011352,0.0003387594,0.0004132758,0.0001573218],"domain_scores_gemma":[0.9965017,0.002361047,0.000536561,0.0002168074,0.0001652798,0.0002185737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0412054,0.001018687,0.9398345,0.0006162368,0.001955126,0.00003970607,0.006962281,0.001238001,0.003378172,0.00007733655,0.0000870689,0.003587491],"study_design_scores_gemma":[0.01261753,0.003020573,0.9712792,0.0002697992,0.006044657,4.628493e-7,0.00007381583,0.006223655,0.0002045312,0.0001179992,0.00005353861,0.00009423483],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964338,0.000841168,0.00009940682,0.001765915,0.00005722696,0.0006158917,0.0001751028,0.000004486354,0.000006996327],"genre_scores_gemma":[0.9977302,0.0006803633,0.0001053769,0.0004195688,0.00003338961,0.00002555818,0.0009932951,0.000009383735,0.000002843109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03144471,"threshold_uncertainty_score":0.5564219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03144462576707074,"score_gpt":0.3047405961767824,"score_spread":0.2732959704097117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}