{"id":"W2563890329","doi":"10.1093/ndt/gfv191.43","title":"SP323EFFECTS OF RVX-208, A FIRST IN CLASS EPIGENETIC BET INHIBITOR, ON KEY RENAL PARAMETERS IN SUBJECTS WITH A HISTORY OF CVD, AND CHRONIC KIDNEY DISEASE (CKD); A POST-HOC ANALYSIS OF PATIENTS FROM THE ASSERT, SUSTAIN AND ASSURE CLINICAL TRIALS","year":2015,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Biomedical Ethics and Regulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Medicine; Post-hoc analysis; BET inhibitor; Kidney disease; Internal medicine; Disease; Epigenetics; Endocrinology; Bromodomain; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00215981,0.0006264813,0.002342853,0.0002454809,0.0002357729,0.0004692835,0.0003202882,0.0005441417,0.003609919],"category_scores_gemma":[0.001026119,0.0002874561,0.001569682,0.0002010084,0.0003979065,0.0003709361,0.0003179295,0.001046555,0.0003036154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002895645,"about_ca_system_score_gemma":0.0006044212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003780413,"about_ca_topic_score_gemma":0.0009286613,"domain_scores_codex":[0.9992557,0.0004163041,0.00005478874,0.0001007698,0.00006178155,0.0001105681],"domain_scores_gemma":[0.9991044,0.0003538954,0.0001935549,0.00007993809,0.00007066577,0.000197524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9762864,0.001912966,0.006964924,0.0001834352,0.001165609,0.00003482244,0.00003053505,0.0001931652,0.005049584,0.00002326756,0.0003088243,0.007846529],"study_design_scores_gemma":[0.3260456,0.5286751,0.1278644,0.00005142766,0.005699661,0.0002402223,0.000152807,0.001879694,0.006990187,0.0001798755,0.002178488,0.0000425309],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975655,0.0009960828,0.0001283851,0.00005959348,0.0000368714,0.0002941931,0.0004392784,0.00001365706,0.0004663934],"genre_scores_gemma":[0.9970077,0.0003741237,0.0002865859,0.0000740882,0.00006787636,0.0004458134,0.0005622135,0.000005423218,0.001176177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003609919,"threshold_uncertainty_score":0.01207638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03144462576707074,"score_gpt":0.3047405961767824,"score_spread":0.2732959704097117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}