{"id":"W2563910394","doi":"10.1016/j.cgh.2016.09.108","title":"A Phase 3 Study of Tenofovir Alafenamide (TAF) Compared With Tenofovir Disoproxil Fumarate (TDF) in Patients With HBeAg-negative, Chronic Hepatitis B (CHB): Week 48 Efficacy and Safety Results","year":2016,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; Toronto General Hospital","funders":"","keywords":"Medicine; Tenofovir alafenamide; Internal medicine; Gastroenterology; HBeAg; Renal function; Population; Cobicistat; Creatinine; Urology; Hepatitis B virus; Viral load; Immunology; Human immunodeficiency virus (HIV); HBsAg","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002266518,0.001945651,0.003359453,0.0006626694,0.0007202125,0.001091715,0.0011327,0.001877629,0.004538173],"category_scores_gemma":[0.001891592,0.0009390371,0.003164348,0.0005383986,0.00138645,0.001493602,0.0003213848,0.003974075,0.0008723622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008714288,"about_ca_system_score_gemma":0.001536901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001989936,"about_ca_topic_score_gemma":0.003879341,"domain_scores_codex":[0.999158,0.000438497,0.00004446812,0.0001376104,0.00006165938,0.0001597676],"domain_scores_gemma":[0.9982874,0.0005327975,0.0002921403,0.0001670159,0.0001029771,0.000617697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9570047,0.01720549,0.0009171324,0.000288356,0.0008010058,0.00006382239,0.0001132303,0.0004670602,0.007231862,0.00006529615,0.00055179,0.01529031],"study_design_scores_gemma":[0.7538924,0.2404175,0.003369494,0.00001999956,0.0004220809,0.00007181735,0.00003474507,0.0003013108,0.0009347604,0.00008397717,0.0004261988,0.00002562412],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923468,0.002676968,0.0006086014,0.0003811735,0.0001858618,0.00161621,0.0009945635,0.00009494193,0.001094929],"genre_scores_gemma":[0.9910494,0.00172553,0.001575192,0.0006308745,0.0002799701,0.001908183,0.001018804,0.00004061552,0.001771312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004538173,"threshold_uncertainty_score":0.01518172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02669176578738012,"score_gpt":0.3155335283295468,"score_spread":0.2888417625421667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}