{"id":"W2563922287","doi":"10.1158/1538-7445.am2015-4990","title":"Abstract 4990: The RET receptor Y791F variant activates the kinase but diminishes ligand responsiveness","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Congenital gastrointestinal and neural anomalies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Glial cell line-derived neurotrophic factor; Proto-Oncogene Proteins c-ret; GDNF family of ligands; Receptor tyrosine kinase; Neurotrophic factors; Multiple endocrine neoplasia type 2; Biology; Cancer research; Tyrosine kinase; Endocrinology; Mutation; Internal medicine; Receptor; Cell biology; Signal transduction; Germline mutation; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009137298,0.0005005985,0.0002259502,0.0001439632,0.0001755625,0.0001898803,0.0002631555,0.0003598721,0.003902926],"category_scores_gemma":[0.0001140122,0.0001237379,0.0002676953,0.0001170763,0.0002313778,0.0001113104,0.0001847749,0.0005975008,0.001320279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003537071,"about_ca_system_score_gemma":0.0001923742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331099,"about_ca_topic_score_gemma":0.001219613,"domain_scores_codex":[0.9998247,0.000029745,0.00001736328,0.0000273535,0.00005411889,0.0000467574],"domain_scores_gemma":[0.9999366,0.00001391562,0.0000144903,0.000007316594,0.000005579021,0.00002200246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009521557,0.00002316626,0.00008655631,0.00001409147,0.00000527718,0.0001698569,0.000004946929,0.00002577511,0.9990239,0.00006726261,0.00009070573,0.0003932239],"study_design_scores_gemma":[0.00004299027,0.0003129147,0.004040859,0.000006924199,0.00001200033,0.001163554,0.00001663029,0.0005159825,0.9896109,0.00004182315,0.004228855,0.000006530646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931571,0.001122092,0.0008713104,0.0002282011,0.000133423,0.00003238691,0.001140547,0.00006173913,0.003253211],"genre_scores_gemma":[0.9910421,0.0005959184,0.0009313473,0.0001551893,0.0000351282,0.00004425853,0.001573974,0.00004359148,0.005578525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003902926,"threshold_uncertainty_score":0.01305652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1793328882236449,"score_gpt":0.3977012412551965,"score_spread":0.2183683530315516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}