{"id":"W2563946775","doi":"10.1158/1538-7445.am2015-2750","title":"Abstract 2750: Modulation of BRCA1 expression as a preventative method for BRCA1-associated breast cancer","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; University of Alberta","funders":"","keywords":"Breast cancer; Haploinsufficiency; Medicine; Population; Cancer; Mutation; Tamoxifen; Oncology; Cancer research; Gene; Genetics; Biology; Bioinformatics; Internal medicine; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002252962,0.0002288791,0.0003123013,0.0003229293,0.0001427167,0.0001668671,0.0002455682,0.0001558621,0.003307505],"category_scores_gemma":[0.0003223852,0.00008670917,0.0001661504,0.0002048527,0.0001832339,0.000081554,0.0001135552,0.0002638419,0.0004313958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997788,"about_ca_system_score_gemma":0.0003314761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004298718,"about_ca_topic_score_gemma":0.0005678721,"domain_scores_codex":[0.999896,0.00002262125,0.000006764334,0.00002372041,0.00003518162,0.00001567617],"domain_scores_gemma":[0.9999093,0.00003024226,0.00002065193,0.000008174165,0.00001182735,0.00001989254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004724454,0.001575988,0.02678275,0.000380522,0.00006165296,0.0001749904,0.00006524868,0.0003228853,0.8863866,0.0001236833,0.002135746,0.07726555],"study_design_scores_gemma":[0.0005523653,0.01896923,0.3563697,0.00006517251,0.0002558152,0.001278286,0.000125129,0.002600654,0.6045129,0.0002556915,0.01498989,0.00002527715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9947394,0.001509093,0.001458066,0.0001384234,0.00004728502,0.0001211013,0.0006200176,0.00009701627,0.001269693],"genre_scores_gemma":[0.9853394,0.001343156,0.007089333,0.0001658732,0.00005559161,0.000267858,0.001516995,0.00002662486,0.004195309],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003307505,"threshold_uncertainty_score":0.01106465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0850835620187684,"score_gpt":0.4663933789210913,"score_spread":0.3813098169023229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}