{"id":"W2563967614","doi":"10.1182/blood.v114.22.934.934","title":"A Phase I Study of GA101 (RO5072759) Monotherapy Followed by Maintenance in Patients with Multiply Relapsed/Refractory CD20+ Malignant Disease.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; University of British Columbia; London Health Sciences Centre; Jewish General Hospital; Princess Margaret Cancer Centre; BC Cancer Agency","funders":"","keywords":"Medicine; Tolerability; Maintenance therapy; Rituximab; Internal medicine; Dosing; Neutropenia; Refractory (planetary science); Follicular lymphoma; Cohort; Clinical trial; Phases of clinical research; Surgery; Adverse effect; Oncology; Gastroenterology; Lymphoma; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001091643,0.001520516,0.002342955,0.0005400422,0.0005095182,0.0008054813,0.001197459,0.001042477,0.00264071],"category_scores_gemma":[0.0007803869,0.0006522898,0.001087081,0.0005496371,0.001068318,0.0006437709,0.0002932914,0.002697742,0.0009765876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001610569,"about_ca_system_score_gemma":0.002185779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004359597,"about_ca_topic_score_gemma":0.009171091,"domain_scores_codex":[0.9996239,0.0001299486,0.0000171323,0.000074622,0.00004179939,0.0001124737],"domain_scores_gemma":[0.9992148,0.0001132928,0.0001115795,0.00007136897,0.00003313573,0.0004558313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6905073,0.1122179,0.008460889,0.000793602,0.001286685,0.0007749681,0.0004653322,0.002429408,0.05543242,0.0002767852,0.003402269,0.1239526],"study_design_scores_gemma":[0.3378192,0.6450509,0.01202403,0.000022329,0.000281598,0.0003688978,0.00004126191,0.0006988294,0.00229,0.00008634054,0.001290863,0.00002573434],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937865,0.001483617,0.0003175861,0.0002568199,0.00009885363,0.001938889,0.0004954438,0.00008180059,0.001540562],"genre_scores_gemma":[0.9927261,0.001403502,0.00117507,0.0004624851,0.0001529102,0.001361774,0.00118407,0.00002027857,0.001513884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004359597,"threshold_uncertainty_score":0.01168549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165317677638131,"score_gpt":0.284161255184567,"score_spread":0.2725080784081857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}