{"id":"W2564036615","doi":"10.1161/res.117.suppl_1.18","title":"Abstract 18: Increasing in vivo Apoa1/HDL Levels Negates the Cardiotoxic Effects of Doxorubicin, and Involves Signalling Through SR-BI, PI3K, and AKT1","year":2015,"lang":"en","type":"article","venue":"Circulation Research","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Cardiotoxicity; Apoptosis; In vivo; AKT1; Gene knockdown; Medicine; Pharmacology; Doxorubicin; Knockout mouse; Protein kinase B; PI3K/AKT/mTOR pathway; Cardiac function curve; Heart failure; Endocrinology; Internal medicine; Chemistry; Biology; Toxicity; Receptor; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383905,0.0003978962,0.0003666803,0.0001892821,0.000139228,0.0003319264,0.0001986672,0.0002710789,0.00487748],"category_scores_gemma":[0.00009354568,0.0001465451,0.0002415856,0.0001237399,0.0002110434,0.0002678559,0.0001614234,0.000747547,0.000951848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479351,"about_ca_system_score_gemma":0.0002576544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003045018,"about_ca_topic_score_gemma":0.0004574206,"domain_scores_codex":[0.9998829,0.00001168533,0.00001700711,0.00003445874,0.00002678625,0.00002709098],"domain_scores_gemma":[0.9998702,0.00001129046,0.00004795997,0.00001395625,0.00001565416,0.00004105893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003720061,0.00006932775,0.0001409685,0.00006610393,0.000006313299,0.00002632416,0.000006130379,0.00001948184,0.9972112,0.00005438552,0.0001556477,0.001872204],"study_design_scores_gemma":[0.00007019929,0.0008862643,0.003318695,0.000008899444,0.00002668208,0.0001922623,0.000008852448,0.000291793,0.9924343,0.00003593463,0.002722536,0.000003646297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872522,0.002488938,0.004523484,0.0004998207,0.0002235579,0.00007327229,0.00157607,0.0003572275,0.003005396],"genre_scores_gemma":[0.978496,0.001676156,0.004093671,0.0002408499,0.00006898892,0.000113737,0.002512137,0.0001067816,0.01269176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00487748,"threshold_uncertainty_score":0.01631677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1469812910189932,"score_gpt":0.3799851782375988,"score_spread":0.2330038872186057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}