{"id":"W2564043830","doi":"10.1021/acsnano.6b06245","title":"Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood","year":2016,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs; University Health Network; University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Association for the Study of the Liver","keywords":"CD163; Macrophage; Kupffer cell; Phenotype; Cell biology; Mononuclear phagocyte system; Monocyte; Chemistry; Biology; Immunology; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00006914602,0.0001493062,0.0001793679,0.00002569598,0.0001619727,0.00001476295,0.000192136,0.000160071,0.001517219],"category_scores_gemma":[0.00003193905,0.0001044368,0.00003043203,0.0000442433,0.0002775966,0.000100165,0.0001301699,0.00007243918,0.0007890057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001431064,"about_ca_system_score_gemma":0.00001359312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001755281,"about_ca_topic_score_gemma":0.00002995002,"domain_scores_codex":[0.9991337,0.00006743077,0.0001875376,0.0002888717,0.00002484403,0.0002976233],"domain_scores_gemma":[0.9994494,0.0001196754,0.00006804936,0.0003120431,0.00003289059,0.00001789126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003337691,0.00005900143,0.002425733,0.000004199515,0.00009139098,0.000007758462,0.0001613794,9.398592e-9,0.9717296,0.00007703801,0.008192384,0.01721816],"study_design_scores_gemma":[0.001602095,0.0001145529,0.005285751,0.00002660633,0.00006543845,0.00001257211,0.00001589882,5.583903e-8,0.9416757,0.0002474048,0.0507953,0.0001586411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766101,0.02219465,0.000005431988,0.0001798168,0.0004649795,0.00009243716,0.00006990803,0.0000619986,0.0003206605],"genre_scores_gemma":[0.9869885,0.0004752469,0.0000508468,0.0001915496,0.00003997636,0.00001387281,0.00001839857,0.00002196825,0.01219963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04260292,"threshold_uncertainty_score":0.999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009017916708374811,"score_gpt":0.2186570332686928,"score_spread":0.209639116560318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}