{"id":"W2564043830","doi":"10.1021/acsnano.6b06245","title":"Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood","year":2016,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs; University Health Network; University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Association for the Study of the Liver","keywords":"CD163; Macrophage; Kupffer cell; Phenotype; Cell biology; Mononuclear phagocyte system; Monocyte; Chemistry; Biology; Immunology; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000217622,0.0001134857,0.0001496493,0.0001478842,0.00009909932,0.000278066,0.00006190888,0.0001733882,0.001007678],"category_scores_gemma":[0.0002417603,0.0001191133,0.00008921405,0.0001067316,0.00009610901,0.0001234817,0.0001183242,0.0001452983,0.0004673144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001003094,"about_ca_system_score_gemma":0.00009960666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008165532,"about_ca_topic_score_gemma":0.001052998,"domain_scores_codex":[0.9998773,0.00003805144,0.000009275116,0.00002537268,0.00002241618,0.00002753612],"domain_scores_gemma":[0.9999251,0.0000230998,0.00001074064,0.000006121866,0.00002626946,0.000008715992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002027781,0.00001346718,0.002069178,0.00002628906,0.000002816941,0.00006043783,0.00006443662,0.00002851442,0.9958227,0.00005834597,0.0000455137,0.001605497],"study_design_scores_gemma":[0.00003406686,0.0004784591,0.03634156,0.00001529997,0.00002867164,0.0008102593,0.00028284,0.001380258,0.9561509,0.0001679528,0.00429365,0.00001603075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947943,0.001228784,0.002301502,0.00005843744,0.000008060127,0.00002047098,0.0001370802,0.00001736836,0.001433943],"genre_scores_gemma":[0.9958462,0.0005800418,0.001634863,0.00006725769,0.000006112881,0.00003127234,0.0002141254,0.00001283688,0.001607371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001007678,"threshold_uncertainty_score":0.003371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009017916708374811,"score_gpt":0.2186570332686928,"score_spread":0.209639116560318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}