{"id":"W2564058179","doi":"10.1128/jvi.02219-16","title":"Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Gp41; Ectodomain; Biology; Trimer; Glycoprotein; Heptad repeat; Conformational change; Coiled coil; Viral entry; Protein structure; Plasma protein binding; Viral envelope; Biophysics; Biochemistry; Receptor; Cell biology; Virology; Virus; Peptide sequence; Chemistry; Viral replication; Antibody; Epitope; Genetics; Dimer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083728,0.0002253746,0.0001858718,0.0001099228,0.0001636515,0.0002670089,0.0002144904,0.0002520185,0.001488957],"category_scores_gemma":[0.0001809692,0.0001490781,0.0001908581,0.00008088869,0.0001846607,0.0001586491,0.0001428023,0.000371275,0.0002993659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003433879,"about_ca_system_score_gemma":0.000111004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005377042,"about_ca_topic_score_gemma":0.0007166806,"domain_scores_codex":[0.9999069,0.00001987792,0.000007592998,0.00001374547,0.00002165442,0.00003018214],"domain_scores_gemma":[0.9998989,0.0000248347,0.00003173122,0.000007343644,0.00001138099,0.00002589962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003543247,0.00008017508,0.0002936038,0.00002010269,0.00001402134,0.00006642039,0.000009748404,0.0002363983,0.9978057,0.0001006455,0.00003749243,0.0009814173],"study_design_scores_gemma":[0.00009534639,0.0006119413,0.01447534,0.00001234095,0.0000363454,0.0003023607,0.00002600054,0.002888454,0.9801363,0.00009562095,0.001308864,0.00001122846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998395,0.0004594535,0.00032011,0.00002488208,0.000009613559,0.00001734278,0.00008040197,0.00001562663,0.0006775511],"genre_scores_gemma":[0.998993,0.0002036571,0.0002498972,0.00004538605,0.000003901306,0.00001230027,0.0001223884,0.000008704927,0.0003606991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488957,"threshold_uncertainty_score":0.004981041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135587908168757,"score_gpt":0.244648785150253,"score_spread":0.2332929060685654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}