{"id":"W2564086249","doi":"10.1158/1538-7445.am2015-ct226","title":"Abstract CT226: A pilot study of adoptive cell therapy with in vitro educated MART1 T cells in combination with ipilimumab for the treatment of metastatic melanoma","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Leukapheresis; Ipilimumab; CD80; Immunotherapy; Immunology; Priming (agriculture); CD8; Cell therapy; Antigen-presenting cell; T cell; Antigen; Cytotoxic T cell; Internal medicine; Oncology; Immune system; CD40; In vitro; Cell; Stem cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007580525,0.001188206,0.001254238,0.0004410458,0.0005820917,0.0006857707,0.0008092255,0.0007711308,0.003141325],"category_scores_gemma":[0.000444981,0.0003338525,0.0008322072,0.0003620561,0.0006457705,0.0004516448,0.0002884301,0.002555092,0.0009025356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004504212,"about_ca_system_score_gemma":0.001020981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001912198,"about_ca_topic_score_gemma":0.002186182,"domain_scores_codex":[0.9996424,0.0001378028,0.00002224597,0.00005857592,0.00005998903,0.00007903553],"domain_scores_gemma":[0.9996617,0.00006179421,0.00003803264,0.00004944749,0.00002467822,0.0001644249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07303509,0.1561492,0.002251651,0.0007350026,0.0004519057,0.001547754,0.0006734082,0.002926162,0.711872,0.0003729911,0.001528948,0.04845596],"study_design_scores_gemma":[0.01767655,0.8937674,0.005501336,0.00002107333,0.0003323755,0.0007205781,0.00005740915,0.0009799888,0.07840149,0.00006429759,0.002454585,0.00002298815],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961803,0.0004013073,0.0005419265,0.0001316519,0.00007714183,0.001117736,0.0003566347,0.00004364133,0.001149575],"genre_scores_gemma":[0.9948789,0.0006440199,0.0008676394,0.0001123788,0.0001325105,0.0007791065,0.0006302554,0.00001740905,0.001937769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003141325,"threshold_uncertainty_score":0.01050872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1799020407496536,"score_gpt":0.4271268304117442,"score_spread":0.2472247896620906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}