{"id":"W2564137162","doi":"10.1124/mol.116.106161","title":"Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism","year":2017,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Biology; Warburg effect; Glycolysis; PKM2; Biochemistry; Cell biology; Metabolism; Pyruvate kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783097,0.0001138185,0.0001794207,0.0002058507,0.0001489613,0.0003967159,0.0001048344,0.0002008718,0.001110339],"category_scores_gemma":[0.0001969896,0.0001289813,0.0001996625,0.0002205082,0.0001406192,0.0002183624,0.000165907,0.0003372027,0.000180399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003097972,"about_ca_system_score_gemma":0.0001447118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008118381,"about_ca_topic_score_gemma":0.001430701,"domain_scores_codex":[0.9998882,0.00004343098,0.000007786685,0.00001930682,0.00001822064,0.00002309829],"domain_scores_gemma":[0.999889,0.00002492735,0.00003015939,0.000010957,0.00002083457,0.00002407251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001211402,0.00003400971,0.006479367,0.00004852992,0.0000483945,0.0003203904,0.00004962215,0.000114221,0.9827579,0.000682131,0.000208594,0.008045443],"study_design_scores_gemma":[0.00008432289,0.0008717812,0.2589053,0.00002728233,0.0001729037,0.003231493,0.0003030394,0.002806883,0.723033,0.001219562,0.009319871,0.00002461089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877869,0.009196961,0.0009431637,0.0005543712,0.00004004485,0.000004497572,0.0001478965,0.00001872831,0.001307289],"genre_scores_gemma":[0.9958831,0.002049686,0.0004191217,0.0001073557,0.00003137853,0.000006286392,0.0002132973,0.000006995757,0.001282859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001110339,"threshold_uncertainty_score":0.003714502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01495431108264922,"score_gpt":0.3406940774677258,"score_spread":0.3257397663850766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}