{"id":"W2564350518","doi":"10.1124/jpet.116.236224","title":"Bruton’s Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Bruton's tyrosine kinase; Medicine; Inflammation; Endocrinology; Internal medicine; Tyrosine kinase; Pharmacology; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000273219,0.001565388,0.0007649274,0.001991603,0.0005247756,0.0005616468,0.0004361839,0.000827704,0.003585559],"category_scores_gemma":[0.0003024185,0.0006731132,0.001020576,0.0006339408,0.0009813341,0.0009836813,0.0003681719,0.002468618,0.0006493856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006406912,"about_ca_system_score_gemma":0.0009166792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002165617,"about_ca_topic_score_gemma":0.002551343,"domain_scores_codex":[0.999712,0.0000310807,0.00002266512,0.00007718737,0.00004985322,0.0001071701],"domain_scores_gemma":[0.9993054,0.0001127144,0.0001752045,0.0001214994,0.00006535802,0.0002197552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01601002,0.003037236,0.001812249,0.0001379577,0.00009047853,0.0007635196,0.000114251,0.0004382543,0.9668119,0.0006326571,0.0004795891,0.009671889],"study_design_scores_gemma":[0.0003713011,0.01026515,0.005014532,0.00001764017,0.0001366169,0.0004917925,0.0001322782,0.000904612,0.9804898,0.0002124705,0.001936877,0.00002681683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922866,0.001171739,0.002249528,0.000348733,0.0001716824,0.00008806475,0.0008465439,0.0002434054,0.002593784],"genre_scores_gemma":[0.9869723,0.001684818,0.001074464,0.0001856696,0.00006368628,0.00009614663,0.0009522022,0.0000740473,0.008896801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003585559,"threshold_uncertainty_score":0.01199484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03696822092133551,"score_gpt":0.3545127738757606,"score_spread":0.3175445529544251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}