{"id":"W2564350780","doi":"10.1158/1538-7445.am2015-4487","title":"Abstract 4487: Design, synthesis, and biological activity of N-phenyl ureidobenzenesulfonates (PUB-SOs) as new and innovative small-molecule drugs inhibiting proteins involved in DNA repair/replication mechanisms","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Pharmacophore; Cell cycle; Cell cycle checkpoint; DNA repair; Chemistry; DNA damage; DNA replication; Context (archaeology); DNA; Biochemistry; Cell biology; Biology; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040625,0.0001745155,0.0001774026,0.0001296658,0.00007523974,0.0001193376,0.0001742427,0.0001508875,0.001263552],"category_scores_gemma":[0.00006805092,0.00006143299,0.0001678789,0.0001580614,0.0001000468,0.0001292905,0.0001243771,0.0001816263,0.0003580758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001402296,"about_ca_system_score_gemma":0.0002394192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004219212,"about_ca_topic_score_gemma":0.000648444,"domain_scores_codex":[0.9999421,0.00001423466,0.00000496073,0.00001009675,0.00001519421,0.00001346213],"domain_scores_gemma":[0.9999604,0.000003598249,0.00001085479,0.00000395133,0.000006648189,0.00001444828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002176249,0.0001412483,0.0003802263,0.0001679875,0.00001269849,0.0000996236,0.00001896475,0.000606882,0.9870837,0.0004429923,0.0001261103,0.01070207],"study_design_scores_gemma":[0.0001015094,0.002858113,0.003495594,0.00001527439,0.00003387763,0.0002888625,0.00001705841,0.001249815,0.9818687,0.00007637231,0.009983937,0.00001096813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988936,0.002943999,0.004038569,0.00008699648,0.0000291006,0.0001132599,0.0004812943,0.00005657239,0.003314096],"genre_scores_gemma":[0.9915915,0.001766646,0.003811045,0.00005868186,0.000009622529,0.00003593642,0.0004728763,0.000008135596,0.00224553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263552,"threshold_uncertainty_score":0.004227042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1634480726812661,"score_gpt":0.3765244120487926,"score_spread":0.2130763393675264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}