{"id":"W2564558365","doi":"10.1101/cshperspect.a024117","title":"Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS)","year":2016,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"","keywords":"Amyotrophic lateral sclerosis; Progressive muscular atrophy; Phenotype; Upper motor neuron; Lower motor neuron; Atrophy; Motor neuron; Neuroscience; Mutation; Disease; Biology; Pathology; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002239828,0.0009035926,0.006105671,0.00133129,0.00007896288,0.00001922703,0.0008466274,0.0008439235,0.00146284],"category_scores_gemma":[0.001848543,0.0005756866,0.001050393,0.001264606,0.001834597,0.000137053,0.0004404806,0.002201248,0.0001899732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001336847,"about_ca_system_score_gemma":0.0007427759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002477499,"about_ca_topic_score_gemma":0.00001099122,"domain_scores_codex":[0.9926779,0.0007265946,0.002650961,0.00154361,0.001299988,0.001100914],"domain_scores_gemma":[0.9956483,0.0009329999,0.000850042,0.00166952,0.0002950394,0.0006041241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002531983,0.006289775,0.03207847,0.109702,0.008656403,0.003765006,0.002416392,0.000002360216,0.006002164,0.08434763,0.0039524,0.7402554],"study_design_scores_gemma":[0.007718236,0.002681898,0.1289366,0.3084039,0.001691568,0.00003004661,0.0000945408,0.00002178104,0.00002448373,0.0001158292,0.5490545,0.001226646],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004030637,0.9906116,0.00004033344,0.001521577,0.0006430722,0.00206631,0.0000284621,0.0001183086,0.0009397127],"genre_scores_gemma":[0.02784118,0.9682564,0.0003480017,0.00006881231,0.002505158,0.000153938,0.000003762567,0.0002130332,0.0006096862],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7390288,"threshold_uncertainty_score":0.9996694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1470148415120423,"score_gpt":0.4242244214870592,"score_spread":0.2772095799750169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}