{"id":"W2564558365","doi":"10.1101/cshperspect.a024117","title":"Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS)","year":2016,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"","keywords":"Amyotrophic lateral sclerosis; Progressive muscular atrophy; Phenotype; Upper motor neuron; Lower motor neuron; Atrophy; Motor neuron; Neuroscience; Mutation; Disease; Biology; Pathology; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005220586,0.0009504927,0.001649176,0.002954548,0.0002822377,0.0008781177,0.0009207079,0.0009388868,0.005854183],"category_scores_gemma":[0.0006363656,0.0001962668,0.0005256472,0.001684987,0.0004877713,0.0008155735,0.000738233,0.001060098,0.005481258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006026177,"about_ca_system_score_gemma":0.001062652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001412586,"about_ca_topic_score_gemma":0.002425416,"domain_scores_codex":[0.9998153,0.00002732456,0.00003371483,0.00003034903,0.00006909315,0.00002423465],"domain_scores_gemma":[0.9998074,0.00005595785,0.00003243488,0.000007020257,0.00006413765,0.00003310581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000555459,0.00003221194,0.0003482653,0.007272329,0.00006878136,0.0005704971,0.00005640318,0.0001302598,0.001158294,0.002251183,0.04804924,0.9400071],"study_design_scores_gemma":[0.00002344635,0.00004967214,0.001275851,0.003698019,0.00008394793,0.004807773,0.00005842486,0.00003639513,0.0002668822,0.001220126,0.9884641,0.0000153469],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002102181,0.9950752,0.0001710871,0.0004413514,0.0001931142,0.00001067442,0.00006309983,0.00002126714,0.003814069],"genre_scores_gemma":[0.001744343,0.9957249,0.0002942511,0.0004442317,0.0002163196,0.00001260787,0.0001423956,0.000003203103,0.001417842],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005854183,"threshold_uncertainty_score":0.01958424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1470148415120423,"score_gpt":0.4242244214870592,"score_spread":0.2772095799750169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}