{"id":"W2564604721","doi":"10.1182/blood.v124.21.1397.1397","title":"Macrophage NADPH Oxidase Activation and ROS Production Is Positively Regulated By Shp2 Phosphatase Function","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network","funders":"","keywords":"Zymosan; NADPH oxidase; MAPK/ERK pathway; Cell biology; Protein tyrosine phosphatase; Phosphorylation; Biology; Protein kinase B; Phosphatase; Signal transduction; Reactive oxygen species; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001506236,0.0002928773,0.0001517102,0.0001562157,0.0001237351,0.0001866394,0.0001044876,0.0001884917,0.0009553714],"category_scores_gemma":[0.00009412399,0.0001039774,0.0002280592,0.0001166372,0.0001744011,0.0001706019,0.0001835305,0.000363692,0.0002210628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001986218,"about_ca_system_score_gemma":0.0001296154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003559737,"about_ca_topic_score_gemma":0.0003975654,"domain_scores_codex":[0.9998715,0.00002284928,0.000007280447,0.00002621682,0.00002964565,0.00004241828],"domain_scores_gemma":[0.9999367,0.000008193128,0.00001882773,0.000005054108,0.00001029323,0.00002094526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002888923,0.00002145947,0.0004559518,0.00002314494,0.000004161938,0.00004974297,0.000008667922,0.0000226641,0.9985901,0.000057141,0.00002909817,0.0004490452],"study_design_scores_gemma":[0.00002708638,0.0002727763,0.01850855,0.000005662226,0.00001165671,0.0001985353,0.00003827669,0.0009023575,0.9789392,0.00007648957,0.001015568,0.000003795161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951723,0.001417602,0.002103968,0.0000910779,0.00002468797,0.00002284837,0.000246486,0.00003525593,0.0008856703],"genre_scores_gemma":[0.9975868,0.0003668228,0.0006817827,0.00002799454,0.000009207599,0.00003806096,0.0002005495,0.000003615768,0.001085243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009553714,"threshold_uncertainty_score":0.003196061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004567772998095442,"score_gpt":0.2177045084820705,"score_spread":0.2131367354839751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}