{"id":"W2564643093","doi":"10.1038/onc.2016.452","title":"Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Blood properties and coagulation","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute; National Institutes of Health","keywords":"Biology; Tissue transglutaminase; Cancer; Stem cell; Cancer research; Cell survival; Cancer stem cell; Carcinogenesis; Cancer cell; GTP'; Cell biology; Biochemistry; Enzyme; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003542862,0.0001976347,0.0002990144,0.0000467251,0.0001557418,0.00001605246,0.0001255255,0.00009463461,0.0001114277],"category_scores_gemma":[0.000002962999,0.00009703204,0.00009546274,0.0002104873,0.00009445441,0.0001531472,0.00003088776,0.0001208165,0.000007105273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001233884,"about_ca_system_score_gemma":0.0001673473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009869551,"about_ca_topic_score_gemma":0.0005084763,"domain_scores_codex":[0.998585,0.0001919606,0.0003006822,0.0002493139,0.0004034504,0.0002696178],"domain_scores_gemma":[0.9992238,0.00003999074,0.0001728417,0.0003201796,0.0001214599,0.0001217837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006022878,0.00008293227,0.001871267,0.0002321712,0.00004308526,0.000001444077,0.002177585,0.00005812955,0.8971348,0.000002723748,0.00004309409,0.09775052],"study_design_scores_gemma":[0.002132925,0.0001627582,0.01342675,0.0003111946,0.0001755725,0.000001466549,0.0003954301,0.0004548023,0.9813235,0.000001162463,0.001458539,0.0001558876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940982,0.0006374751,0.0002782654,0.002775569,0.0003200989,0.001411169,0.0002315532,0.00002142105,0.000226203],"genre_scores_gemma":[0.9957512,0.0001518084,0.00001616884,0.0001114348,0.0001177121,0.0001413713,0.000004764258,0.00002863563,0.003676911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09759464,"threshold_uncertainty_score":0.3956852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03590888569729658,"score_gpt":0.2714465120572664,"score_spread":0.2355376263599698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}