{"id":"W2564655741","doi":"10.1016/s1525-0016(16)33216-6","title":"407. A Novel Rabbit Antibody-Derived, Anti-CD123 LV/CAR Construct for AML Immunotherapy","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Interleukin-3 receptor; Chimeric antigen receptor; Myelopoiesis; Cancer research; Immunotherapy; Haematopoiesis; Immunology; Immunotoxin; Antibody; Myeloid leukemia; Biology; Antigen; Cytotoxic T cell; Progenitor cell; Cancer immunotherapy; Monoclonal antibody; Stem cell; Immune system; Cell biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005649094,0.0005008692,0.0008090264,0.0003080872,0.0001715093,0.00007596525,0.0004413027,0.0002793857,0.00279017],"category_scores_gemma":[0.00007832807,0.0003500781,0.0006367237,0.0003825469,0.0004559896,0.0001191415,0.00005377879,0.0002579951,0.0001262876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001646169,"about_ca_system_score_gemma":0.0003049671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005486313,"about_ca_topic_score_gemma":0.000002637976,"domain_scores_codex":[0.9968919,0.0001235013,0.0005174836,0.0007890267,0.0007245727,0.0009534747],"domain_scores_gemma":[0.9977166,0.0002283723,0.0001569078,0.00123052,0.0003912739,0.0002763174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002274524,0.0003398257,0.00152726,0.00003171764,0.0006859596,0.00007710844,0.0001712016,0.000001093069,0.8749012,0.0005434945,0.0002403402,0.1192063],"study_design_scores_gemma":[0.02096548,0.001168787,0.002901041,0.000142723,0.00003178203,0.0002065656,0.00005057281,0.00004269327,0.8308089,0.0004767873,0.1427527,0.0004519566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9169128,0.002959362,0.07220608,0.003613859,0.0003188094,0.002465322,0.00009467413,0.0002086925,0.00122039],"genre_scores_gemma":[0.9771131,0.005380688,0.006312556,0.003935626,0.0004252934,0.0002957933,0.00009645365,0.0003523549,0.006088142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1425124,"threshold_uncertainty_score":0.9998951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02658289893574201,"score_gpt":0.327772995134769,"score_spread":0.301190096199027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}