{"id":"W2564655741","doi":"10.1016/s1525-0016(16)33216-6","title":"407. A Novel Rabbit Antibody-Derived, Anti-CD123 LV/CAR Construct for AML Immunotherapy","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Interleukin-3 receptor; Chimeric antigen receptor; Myelopoiesis; Cancer research; Immunotherapy; Haematopoiesis; Immunology; Immunotoxin; Antibody; Myeloid leukemia; Biology; Antigen; Cytotoxic T cell; Progenitor cell; Cancer immunotherapy; Monoclonal antibody; Stem cell; Immune system; Cell biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648052,0.0003845545,0.0002755866,0.0002680871,0.0001898868,0.0003369769,0.0003181163,0.0005508187,0.003403442],"category_scores_gemma":[0.0001078308,0.0002037212,0.0003337882,0.0001411986,0.0002065491,0.0002244718,0.0002486619,0.0007358256,0.001844165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004814321,"about_ca_system_score_gemma":0.0003438008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006129684,"about_ca_topic_score_gemma":0.0004904479,"domain_scores_codex":[0.9998429,0.00002676656,0.00001265863,0.00003483806,0.00004809592,0.00003469582],"domain_scores_gemma":[0.9999413,0.000008180711,0.00001137464,0.000006600952,0.00001048971,0.00002207158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007157248,0.00005720247,0.0001280603,0.00003520515,0.000004447502,0.00005514808,0.00002383922,0.0001519002,0.9941862,0.0006303901,0.0002321998,0.004423723],"study_design_scores_gemma":[0.00004245633,0.0003129804,0.0005576728,0.000006762464,0.00002361334,0.000408356,0.000008068248,0.002364157,0.9804069,0.00008575049,0.01577635,0.000006970837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8998342,0.002153247,0.07833259,0.0006990563,0.0001364854,0.0004862165,0.001128705,0.001198586,0.01603102],"genre_scores_gemma":[0.941525,0.001119443,0.03681851,0.0002432444,0.00003547858,0.0002980079,0.002427344,0.0002300224,0.01730283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003403442,"threshold_uncertainty_score":0.01138568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02658289893574201,"score_gpt":0.327772995134769,"score_spread":0.301190096199027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}