{"id":"W2564709121","doi":"10.1089/aid.2016.0246","title":"Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates","year":2016,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Antibody-dependent cell-mediated cytotoxicity; Virology; Antibody; Epitope; Biology; Neutralization; Simian immunodeficiency virus; Glycoprotein; Virus; Vaccine trial; Immunology; HIV vaccine; Viral envelope; Lentivirus; Cytotoxicity; In vitro; Viral disease; Monoclonal antibody; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603346,0.0005400307,0.0003272016,0.0002024326,0.0001380615,0.0003115655,0.0002627276,0.0005435749,0.007683469],"category_scores_gemma":[0.0002830302,0.0001254634,0.0001385562,0.0001253528,0.0002096603,0.0002183116,0.0001652317,0.0004622393,0.00188024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003253291,"about_ca_system_score_gemma":0.0001071769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002030545,"about_ca_topic_score_gemma":0.0002191082,"domain_scores_codex":[0.9997928,0.00007275192,0.00001372536,0.00003766902,0.00004733453,0.00003584944],"domain_scores_gemma":[0.9998572,0.00005187298,0.0000263356,0.00001289756,0.00002658187,0.00002507127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001405958,0.0002540076,0.0005258379,0.0005421274,0.00003562154,0.000399019,0.00004122948,0.0003370112,0.964451,0.0004324232,0.00334769,0.02822797],"study_design_scores_gemma":[0.0001596914,0.003527105,0.004268961,0.00002122104,0.00005205159,0.0009576759,0.00003249936,0.001086955,0.9564967,0.000207552,0.03318148,0.00000803206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.937282,0.03015806,0.005780773,0.001264297,0.001192382,0.0002896228,0.001032142,0.0004008076,0.02259998],"genre_scores_gemma":[0.9544373,0.008619596,0.003230904,0.0006545499,0.0008934798,0.0001663592,0.0009305275,0.0000543937,0.03101286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007683469,"threshold_uncertainty_score":0.02570373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03268376957576939,"score_gpt":0.3166062339606968,"score_spread":0.2839224643849274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}