{"id":"W2564709121","doi":"10.1089/aid.2016.0246","title":"Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates","year":2016,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Antibody-dependent cell-mediated cytotoxicity; Virology; Antibody; Epitope; Biology; Neutralization; Simian immunodeficiency virus; Glycoprotein; Virus; Vaccine trial; Immunology; HIV vaccine; Viral envelope; Lentivirus; Cytotoxicity; In vitro; Viral disease; Monoclonal antibody; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001210251,0.0004387792,0.0006233918,0.0006324945,0.001036846,0.0001741977,0.0006951221,0.0003355915,0.0003826186],"category_scores_gemma":[0.000366561,0.0003385298,0.00009696004,0.0004726986,0.00115839,0.0001671225,0.0008488793,0.0007202915,0.001023544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002942045,"about_ca_system_score_gemma":0.0001063677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002253346,"about_ca_topic_score_gemma":0.0007478544,"domain_scores_codex":[0.9954939,0.001206878,0.0006104757,0.0008261789,0.0003177882,0.001544732],"domain_scores_gemma":[0.9973857,0.0008338629,0.00008037844,0.001023135,0.000428752,0.0002481273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003598725,0.0006232903,0.1805574,0.00003969625,0.0002115432,0.00005300187,0.0002453158,1.110066e-7,0.811859,0.0000990806,0.005352789,0.0005989596],"study_design_scores_gemma":[0.002446142,0.001527917,0.04445262,0.0001565252,0.0000174324,0.00001005354,0.000205207,3.322064e-7,0.9467469,0.00005772041,0.003986514,0.0003926663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925573,0.003690023,0.0001876283,0.0002680786,0.00002935482,0.0014251,0.001327679,0.000108089,0.0004066946],"genre_scores_gemma":[0.9921702,0.001740857,0.0002473889,0.00005851151,0.00001778303,0.0001521561,0.001306069,0.00006057311,0.004246467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1361047,"threshold_uncertainty_score":0.9999067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03268376957576939,"score_gpt":0.3166062339606968,"score_spread":0.2839224643849274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}