{"id":"W2564718551","doi":"10.1158/1538-7445.panca16-a48","title":"Abstract A48: Multi-omics characterization of PDAC subtypes using PDX reveals that epigenetic but not genetic analysis permit a clinically relevant classification","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre","funders":"","keywords":"Epigenetics; Transcriptome; Carcinogenesis; Biology; Cancer; Exome sequencing; Cancer research; Wnt signaling pathway; Exome; microRNA; Bioinformatics; Medicine; Pathology; Gene; Genetics; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002694532,0.0002932255,0.0004124054,0.0005254757,0.0002511056,0.0008921471,0.0001535253,0.0002331512,0.00181899],"category_scores_gemma":[0.0003087384,0.0001136885,0.0003822396,0.0004657531,0.0001679717,0.0002391459,0.0003841206,0.0005049724,0.0006327903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001694339,"about_ca_system_score_gemma":0.0001987324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003725265,"about_ca_topic_score_gemma":0.0003813701,"domain_scores_codex":[0.9998063,0.00001664493,0.00001822016,0.00007677222,0.00005930732,0.00002270114],"domain_scores_gemma":[0.9998298,0.00003817918,0.00003824222,0.00003422026,0.00003084599,0.00002862866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003922449,0.00005422912,0.0346382,0.0001029209,0.00006366742,0.0001622587,0.00005595326,0.0004313328,0.9508483,0.0001522538,0.0004270914,0.01267152],"study_design_scores_gemma":[0.00005236059,0.0008704636,0.4716406,0.00004779418,0.0002593129,0.002601111,0.000270165,0.01217339,0.4962094,0.0006378461,0.01519995,0.00003753179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797022,0.0007210142,0.00905846,0.0001103275,0.00002620238,0.00007828218,0.008879348,0.0001762915,0.001247872],"genre_scores_gemma":[0.9737077,0.0005071529,0.01073686,0.00008619564,0.0000155605,0.000147594,0.01301633,0.00006083661,0.00172175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181899,"threshold_uncertainty_score":0.006085098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2762846177686377,"score_gpt":0.4822962790034726,"score_spread":0.2060116612348349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}