{"id":"W2564745782","doi":"10.1182/blood.v108.11.752.752","title":"Chronic Myeloid Leukemia Stem Cells Possess Unique Properties That Predict Intrinsic and Acquired Resistance to Imatinib Mesylate.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Imatinib mesylate; Myeloid leukemia; Tyrosine kinase; Cancer research; CD38; Stem cell; Biology; Haematopoiesis; Side population; clone (Java method); Population; Imatinib; Leukemia; Myeloid; CD34; Chemistry; Cell biology; Immunology; Cancer stem cell; Medicine; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125189,0.0001491186,0.0001331282,0.0002682446,0.0001027016,0.000231285,0.00005163926,0.000226616,0.001450489],"category_scores_gemma":[0.0001316285,0.00007958174,0.0001190517,0.000199209,0.0001480498,0.0001255911,0.0001466413,0.0002400265,0.0003038441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001094481,"about_ca_system_score_gemma":0.00006333849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000195497,"about_ca_topic_score_gemma":0.0003296948,"domain_scores_codex":[0.999892,0.00001773834,0.00001243524,0.00001890939,0.00003432408,0.00002465572],"domain_scores_gemma":[0.9998922,0.00002058406,0.00002626346,0.00001163309,0.00001760256,0.00003162388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001652466,0.00002643517,0.008132216,0.00001876149,0.000006077863,0.00005067835,0.00003455268,0.00004118656,0.9896495,0.0001077113,0.00002733243,0.001740202],"study_design_scores_gemma":[0.00004998448,0.001521193,0.3267077,0.00001078859,0.00005983505,0.002586064,0.0002081416,0.001791344,0.6626089,0.0001960014,0.004248295,0.00001172929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982623,0.0002545896,0.0004039208,0.00002022645,0.000003162433,0.0000161176,0.0003363655,0.00001017358,0.0006930846],"genre_scores_gemma":[0.9985325,0.00008818205,0.0003658408,0.00001531819,0.000002730985,0.00001773518,0.0005590239,0.000002318181,0.0004162621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001450489,"threshold_uncertainty_score":0.004852355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501096790724864,"score_gpt":0.2229069007465775,"score_spread":0.2078959328393288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}