{"id":"W2564861566","doi":"10.1016/j.conb.2016.12.002","title":"In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory","year":2016,"lang":"en","type":"review","venue":"Current Opinion in Neurobiology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Institut National de la Santé et de la Recherche Médicale","keywords":"Enhancer; Chromatin; Epigenetics; Biology; Transcription factor; Histone; Regulation of gene expression; Histone code; Computational biology; Topology (electrical circuits); Genetics; Gene; Neuroscience; Cell biology; Nucleosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003480301,0.0003936913,0.0007186875,0.0003104501,0.00005569277,0.00003096901,0.000374787,0.0008075033,0.0000167098],"category_scores_gemma":[0.00009880438,0.0002831425,0.0001042383,0.0002097624,0.00007816133,0.00000500203,0.0003089945,0.0009232812,0.000006106109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006248921,"about_ca_system_score_gemma":0.0001052446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004908932,"about_ca_topic_score_gemma":0.00005458836,"domain_scores_codex":[0.99749,0.0007782626,0.0005086377,0.0007438897,0.00005943519,0.0004197466],"domain_scores_gemma":[0.9992435,0.0001002605,0.0002687252,0.0003180808,0.00002061501,0.00004881172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000976114,0.0002043947,0.0002982499,0.01142955,0.0001019523,0.00001424339,0.0004818529,0.0002792406,0.03641378,0.002819583,0.0005611414,0.9472984],"study_design_scores_gemma":[0.0007113805,0.0007031663,0.0005711712,0.001899096,0.00002683862,0.000160367,0.0001190921,0.00003290623,0.00001173942,0.0009136876,0.9942672,0.000583342],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01910847,0.9745377,0.0007493743,0.0004131848,0.003931393,0.001157239,0.00007187243,0.000009585401,0.00002120933],"genre_scores_gemma":[0.01110683,0.9876387,0.00007203723,0.0001099486,0.0002711527,0.0001246303,0.0005917424,0.00004471288,0.00004024643],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.993706,"threshold_uncertainty_score":0.9999621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04002863010188674,"score_gpt":0.3294166371647803,"score_spread":0.2893880070628936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}