{"id":"W2564947101","doi":"10.1371/journal.pone.0168641","title":"RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"RHOA; CDC42; Cell biology; Stress fiber; Actin; Actin cytoskeleton; Cytoskeleton; Actin remodeling; Small GTPase; Phosphorylation; Chemistry; Biology; Focal adhesion; Biochemistry; Signal transduction; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289333,0.00009149839,0.00009949561,0.00005242483,0.00005326297,0.00001705519,0.0001685829,0.00006711468,0.00009387145],"category_scores_gemma":[0.0004308961,0.00005756487,0.00004544707,0.0001107021,0.00002071202,0.000004459169,0.0001095984,0.00006368076,0.00004893829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002747364,"about_ca_system_score_gemma":0.00003164626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003056122,"about_ca_topic_score_gemma":0.0001508303,"domain_scores_codex":[0.9992054,0.0001320882,0.0001340582,0.0002405206,0.0001197426,0.0001682008],"domain_scores_gemma":[0.9993978,0.00005130035,0.00004892693,0.0003809758,0.00007082685,0.00005022572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005115885,0.000278101,0.000227888,0.000004187094,0.00007242634,0.000001314699,0.00007527664,0.000001560159,0.9975683,0.00003915545,0.0001683854,0.001051789],"study_design_scores_gemma":[0.0002345734,0.0002679562,0.000939244,0.00009354645,0.00001630003,8.536286e-7,0.00008832091,0.0000178805,0.9944854,0.00007115146,0.003684547,0.0001002183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942804,0.00004590805,0.0003405839,0.004727168,0.00002216033,0.0003485671,0.00002780747,0.000007439981,0.000199974],"genre_scores_gemma":[0.9951875,0.00005134807,0.0003812255,0.000149697,0.00008082503,0.0001263623,0.00001246375,0.00001299271,0.003997552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004577471,"threshold_uncertainty_score":0.2347427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835369537850138,"score_gpt":0.2337636996097602,"score_spread":0.2154100042312588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}