{"id":"W2564952670","doi":"10.1128/jvi.02417-16","title":"Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Abrogates NF-κB Activation in DNA Sensing Signal Pathway","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Biology; Innate immune system; Stimulator of interferon genes; Deubiquitinating enzyme; IκB kinase; NF-κB; Herpes simplex virus; Ubiquitin; Cell biology; Interferon; RIG-I; Signal transduction; IκBα; TLR3; Molecular biology; Virology; Virus; Immune system; Gene; Toll-like receptor; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521869,0.000475972,0.0003105963,0.0001826672,0.0001572546,0.0002359087,0.0002476344,0.0002382178,0.001489667],"category_scores_gemma":[0.0000990297,0.0001306333,0.0003249708,0.0001680251,0.0002515175,0.0002047881,0.0002051936,0.0005201931,0.0003924166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003179086,"about_ca_system_score_gemma":0.0001767044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004202363,"about_ca_topic_score_gemma":0.000375566,"domain_scores_codex":[0.9997956,0.00003853533,0.00003068893,0.00003323562,0.00004391012,0.00005808997],"domain_scores_gemma":[0.999885,0.0000189295,0.00003161273,0.00002362573,0.0000103271,0.0000305002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001446201,0.00003910935,0.00005711963,0.00004562563,0.00000549592,0.00002561637,0.000007227641,0.00004047214,0.9990355,0.00007728572,0.0000253729,0.0004966557],"study_design_scores_gemma":[0.00001176262,0.0001974785,0.0007070592,0.000003723434,0.000008438418,0.000117636,0.000009049692,0.0003661407,0.9973236,0.00002604854,0.001226927,0.000002130177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931405,0.003170319,0.00194929,0.00008664612,0.00006276861,0.00002652546,0.0004582728,0.0001049695,0.00100066],"genre_scores_gemma":[0.9965808,0.0006496935,0.0009851509,0.00002759803,0.000008143769,0.00001976391,0.0004542977,0.0000115121,0.001263076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001489667,"threshold_uncertainty_score":0.004983425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695091239779815,"score_gpt":0.2436322582853976,"score_spread":0.2266813458875994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}