{"id":"W2565007565","doi":"10.1182/blood.v108.11.832.832","title":"Obatoclax (GX15-070) Is a Potent Antagonist of Constitutive Mcl-1/Bak Interactions in Intact Mitochondrial Membrane and Synergizes with Bortezomib in Mantle Cell Lymphoma.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; McGill University","funders":"","keywords":"Bcl-2 family; Effector; Biology; Programmed cell death; Small molecule; Chemistry; Pharmacology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716832,0.0005263276,0.0004023519,0.0002769978,0.0001412467,0.0002395432,0.0003373169,0.0002993346,0.001846847],"category_scores_gemma":[0.0001198609,0.0002014921,0.0002671523,0.0002250493,0.0002492475,0.0002105939,0.0001943904,0.0006889185,0.0006237752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002762582,"about_ca_system_score_gemma":0.0002913528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007620858,"about_ca_topic_score_gemma":0.001473349,"domain_scores_codex":[0.9998958,0.00002265101,0.000008106004,0.00001122965,0.0000221554,0.00004005486],"domain_scores_gemma":[0.9999129,0.00002058024,0.00001735137,0.000006192558,0.000006426911,0.00003655407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001323358,0.0003217357,0.0002280875,0.00009846373,0.00002483715,0.00009447462,0.00001996197,0.0001974069,0.9919476,0.00008891691,0.0002834843,0.005371791],"study_design_scores_gemma":[0.0009309848,0.008309695,0.00685408,0.00001475852,0.00005211473,0.0005811906,0.00002859464,0.001670746,0.9784831,0.00005314757,0.003010525,0.00001115206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928658,0.002859175,0.0006283955,0.0001478057,0.00004635657,0.00009088848,0.0004261915,0.0001621571,0.002773201],"genre_scores_gemma":[0.994832,0.001507363,0.0007180391,0.00008111137,0.00001891888,0.00006678106,0.001237295,0.00001411472,0.001524267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846847,"threshold_uncertainty_score":0.006178319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00356723229294221,"score_gpt":0.1991322739383002,"score_spread":0.195565041645358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}