{"id":"W2565056379","doi":"10.1182/blood.v124.21.2121.2121","title":"Pharmacokinetic (PK) and Pharmacodynamic (PD) Results of a Novel, First-in-Class Modulator of Eukaryotic Translation Initiation Factor 5A (eIF5A) in Patients (pts) with Relapsed or Refractory B-Cell Malignancies: Data from a Phase 1-2 Study","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Medicine; Cancer research; Apoptosis; In vivo; Molecular biology; Pharmacology; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001643232,0.0001717141,0.0002615125,0.0001046454,0.00002333392,0.0000070273,0.000239144,0.00007600821,0.00000619208],"category_scores_gemma":[0.00006724227,0.0001483153,0.00002054341,0.000200381,0.00005027276,0.00002408156,0.00006817616,0.00008476045,5.948882e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006392014,"about_ca_system_score_gemma":0.00005731493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001495257,"about_ca_topic_score_gemma":0.0003279834,"domain_scores_codex":[0.99862,0.0000836709,0.0005002563,0.0004620988,0.0001765096,0.0001574809],"domain_scores_gemma":[0.9990269,0.00006602734,0.0002791217,0.0005103213,0.00006318754,0.00005444475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002411924,0.01501899,0.04033795,0.0001138707,0.00009084119,0.000001885103,0.0007152683,0.000150481,0.9378341,0.000001376422,0.0000262204,0.003297097],"study_design_scores_gemma":[0.2148741,0.004649262,0.4352836,0.0001795775,0.0006760472,0.00000207938,0.0002459026,0.02345388,0.3188267,0.000009093705,0.001089897,0.0007097779],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958322,0.0002263709,0.0005299976,0.00001712107,0.000031018,0.0007392,0.002571133,0.00000613244,0.00004683951],"genre_scores_gemma":[0.9975296,0.0001017951,0.0005195014,0.00001914479,0.00003486504,0.0000393185,0.001727156,0.00001872295,0.000009879904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6190074,"threshold_uncertainty_score":0.6048123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630048746202491,"score_gpt":0.2814800260140191,"score_spread":0.2551795385519942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}