{"id":"W2565056379","doi":"10.1182/blood.v124.21.2121.2121","title":"Pharmacokinetic (PK) and Pharmacodynamic (PD) Results of a Novel, First-in-Class Modulator of Eukaryotic Translation Initiation Factor 5A (eIF5A) in Patients (pts) with Relapsed or Refractory B-Cell Malignancies: Data from a Phase 1-2 Study","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Medicine; Cancer research; Apoptosis; In vivo; Molecular biology; Pharmacology; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009341384,0.000900086,0.001590909,0.0003475777,0.0002656375,0.0006921419,0.0004318424,0.0007883034,0.002391163],"category_scores_gemma":[0.0007304309,0.0003429876,0.001402612,0.0003949412,0.0005534376,0.0006558735,0.0001609196,0.001882655,0.000623126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006144081,"about_ca_system_score_gemma":0.0005373819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000451953,"about_ca_topic_score_gemma":0.0009455573,"domain_scores_codex":[0.9996835,0.0001431306,0.00002209322,0.00006262269,0.00003842749,0.00005032743],"domain_scores_gemma":[0.9994785,0.000118241,0.0001381535,0.00003866293,0.00003372668,0.0001926727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5745344,0.03351445,0.0118699,0.001122863,0.002347232,0.000497489,0.0003834199,0.005934182,0.1979301,0.0003313125,0.00482293,0.1667118],"study_design_scores_gemma":[0.1976259,0.7136308,0.04748791,0.00008064022,0.001926743,0.001071742,0.000153959,0.003350744,0.02645021,0.0004375013,0.007694844,0.00008905483],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920948,0.003942182,0.0008329494,0.0002691636,0.00006376189,0.0005885928,0.0009580397,0.00008494555,0.001165556],"genre_scores_gemma":[0.9929763,0.002041102,0.0009559413,0.0003137205,0.00008785191,0.0006266593,0.001217167,0.00003753449,0.001743913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002391163,"threshold_uncertainty_score":0.007999241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02630048746202491,"score_gpt":0.2814800260140191,"score_spread":0.2551795385519942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}