{"id":"W2565057278","doi":"10.1093/neuonc/now236","title":"Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; University of Calgary; Centre Hospitalier de l’Université de Montréal","funders":"University of California, San Francisco; National Cancer Institute; NRG Oncology; Ohio State University","keywords":"Temozolomide; Medicine; Anaplastic astrocytoma; Internal medicine; Nitrosourea; Radiation therapy; Hazard ratio; Oncology; Progression-free survival; Dacarbazine; Phases of clinical research; Toxicity; Astrocytoma; Gastroenterology; Glioma; Chemotherapy; Confidence interval; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004117826,0.001402167,0.002958429,0.0004740644,0.0004142217,0.0008595691,0.0009646363,0.001241747,0.003969467],"category_scores_gemma":[0.002126175,0.0005913785,0.002035385,0.0005840926,0.0008760443,0.0005170117,0.000408892,0.002783926,0.0006744241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009782438,"about_ca_system_score_gemma":0.002660142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001321842,"about_ca_topic_score_gemma":0.003340701,"domain_scores_codex":[0.9987418,0.0009566583,0.000043999,0.00009007059,0.0000717384,0.00009565735],"domain_scores_gemma":[0.9982686,0.0005514681,0.0004161172,0.0001240012,0.0001042438,0.0005355625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9716036,0.009115287,0.001164065,0.0002124376,0.0008563448,0.00003292186,0.000050078,0.0005483422,0.002707825,0.00006018423,0.0007528677,0.01289598],"study_design_scores_gemma":[0.8860039,0.1089145,0.002618132,0.00002184138,0.0005601962,0.00004460667,0.0000178503,0.000548122,0.0004556328,0.00009817086,0.0007070985,0.00001005683],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871197,0.002861635,0.001058206,0.0006050783,0.0002867739,0.005386982,0.001158621,0.00009294511,0.001430109],"genre_scores_gemma":[0.9788253,0.002794761,0.003528953,0.001345931,0.0003430347,0.008691855,0.001665991,0.00005476299,0.002749465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004117826,"threshold_uncertainty_score":0.02177745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277421580249684,"score_gpt":0.3396604815050475,"score_spread":0.3119183234800791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}