{"id":"W2565057278","doi":"10.1093/neuonc/now236","title":"Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; University of Calgary; Centre Hospitalier de l’Université de Montréal","funders":"University of California, San Francisco; National Cancer Institute; NRG Oncology; Ohio State University","keywords":"Temozolomide; Medicine; Anaplastic astrocytoma; Internal medicine; Nitrosourea; Radiation therapy; Hazard ratio; Oncology; Progression-free survival; Dacarbazine; Phases of clinical research; Toxicity; Astrocytoma; Gastroenterology; Glioma; Chemotherapy; Confidence interval; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005676718,0.0002005661,0.001231713,0.0002478285,0.00006141928,0.000004843501,0.00005218306,0.0001783836,0.00001036239],"category_scores_gemma":[0.001419243,0.0001308703,0.0001011065,0.0001195289,0.0002110735,0.00006680788,0.00002800763,0.00008216114,9.956256e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001591784,"about_ca_system_score_gemma":0.0001773338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005167375,"about_ca_topic_score_gemma":0.0001063537,"domain_scores_codex":[0.9980289,0.0004536451,0.000748365,0.0003855514,0.0001566547,0.0002268578],"domain_scores_gemma":[0.9919216,0.00694121,0.0006474328,0.000213686,0.0001439995,0.0001320624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6208614,0.004412123,0.001409487,0.00001892686,0.0004604425,0.0000441553,0.0009085193,0.000004282622,0.129001,0.00005479597,0.0006265973,0.2421983],"study_design_scores_gemma":[0.8585973,0.08434859,0.002708516,0.00001756305,0.0006785729,0.00003669703,0.0002813023,0.0002071183,0.04909805,0.00003651231,0.003900518,0.0000892119],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939386,0.0005283201,0.00009582398,0.001648719,0.000378187,0.003182005,0.00007003704,0.0000217328,0.0001365281],"genre_scores_gemma":[0.9980271,0.001121763,0.0001644128,0.0001036658,0.0001248765,0.0003985634,0.00003362414,0.00002050953,0.000005519025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2421091,"threshold_uncertainty_score":0.5336736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277421580249684,"score_gpt":0.3396604815050475,"score_spread":0.3119183234800791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}