{"id":"W2565090883","doi":"10.1158/1538-7445.am2015-5341","title":"Abstract 5341: Bifunctional integrated molecules with combined retinoic acid receptor agonist/protein deacetylase inhibitory activities as therapeutic agents for breast cancer and neuroblastoma","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Concordia University; Université de Montréal","funders":"","keywords":"Retinoic acid receptor; Retinoic acid receptor beta; Retinoic acid; Cancer research; Retinoic acid receptor alpha; Retinoic acid receptor gamma; Vorinostat; Pharmacology; Neuroblastoma; Romidepsin; Tretinoin; Biology; Clonogenic assay; Histone deacetylase; Chemistry; Cell culture; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266112,0.0003640797,0.0002645166,0.0002505608,0.00008047784,0.0002341193,0.0002587464,0.0002873235,0.001445275],"category_scores_gemma":[0.00005600758,0.0001287106,0.0002510613,0.0002145641,0.0001217666,0.0001519987,0.0001775246,0.0003734106,0.0005772447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003569628,"about_ca_system_score_gemma":0.0001081314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004580641,"about_ca_topic_score_gemma":0.0007142925,"domain_scores_codex":[0.9999001,0.00001471704,0.000005973907,0.00002195077,0.00003526701,0.00002195496],"domain_scores_gemma":[0.9999716,0.000003256079,0.000008267706,0.000002973653,0.000004777089,0.000009206324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001162673,0.00005853768,0.00007863266,0.00008200954,0.00001661837,0.00006848279,0.00001289812,0.0002840312,0.9913716,0.0003419313,0.000166061,0.007402764],"study_design_scores_gemma":[0.00008748869,0.001395179,0.001391575,0.00001622451,0.00007164329,0.0003231198,0.00001328659,0.0009660464,0.9767259,0.00005949006,0.01893652,0.00001363672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533554,0.01842739,0.01303764,0.0002894448,0.000188972,0.0002879076,0.001396258,0.0003603493,0.01265666],"genre_scores_gemma":[0.9745392,0.006087416,0.01065842,0.0001445607,0.00002226808,0.0001340276,0.001124259,0.00004181084,0.007247997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445275,"threshold_uncertainty_score":0.00483489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04462532649323474,"score_gpt":0.3451804363372964,"score_spread":0.3005551098440617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}