{"id":"W2565093580","doi":"10.1182/blood.v104.11.1797.1797","title":"Variant Forms of Human Interleukin-3 (IL-3) Linked to Truncated Diphtheria Toxin (DT388), Have Enhanced Cytotoxicity Against Acute Myeloid Leukemia (AML) Progenitors.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Diphtheria toxin; Cytotoxicity; Myeloid leukemia; Biology; Fusion protein; Leukemia; Haematopoiesis; Toxin; Progenitor cell; Immunology; Molecular biology; Stem cell; Microbiology; In vitro; Biochemistry; Recombinant DNA; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001001258,0.0002088234,0.0001498074,0.000086788,0.00006025639,0.0001768336,0.0001364512,0.0001838896,0.0006343367],"category_scores_gemma":[0.0001251888,0.00008229562,0.000154997,0.0001101291,0.0001413905,0.0001009766,0.0001325376,0.0003238512,0.0001957238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704975,"about_ca_system_score_gemma":0.00008540854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004160289,"about_ca_topic_score_gemma":0.0004527069,"domain_scores_codex":[0.9999099,0.00001662908,0.00001010744,0.00001369993,0.0000290178,0.00002071287],"domain_scores_gemma":[0.9999386,0.00001165305,0.00002053965,0.000008501072,0.000005492255,0.00001522512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001122738,0.00001467088,0.0002735404,0.000009304237,0.000003678187,0.00003247792,0.000006360587,0.00009121819,0.9989339,0.0000386283,0.00001312666,0.0004708373],"study_design_scores_gemma":[0.00005595979,0.001266098,0.005371997,0.000003729669,0.00002796433,0.0009594056,0.00001694502,0.001031056,0.9889392,0.00002962689,0.00229394,0.000003893477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988254,0.0001917544,0.0005688802,0.00001916905,0.000005871014,0.0000135739,0.0001095229,0.0000105706,0.0002552957],"genre_scores_gemma":[0.997416,0.0001281627,0.001345903,0.00001938137,0.000003141291,0.00001233538,0.0005444685,0.000005657005,0.0005249718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006343367,"threshold_uncertainty_score":0.002122104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009428141731809243,"score_gpt":0.2343413621136284,"score_spread":0.2249132203818191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}