{"id":"W2565202172","doi":"10.1182/blood.v120.21.2085.2085","title":"Eculizumab Is an Effective Treatment for Atypical Hemolytic Uremic Syndrome in Patients with or without Identified Genetic Complement Mutations or Complement Factor H Auto-Antibodies.","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Eculizumab; Atypical hemolytic uremic syndrome; Thrombotic microangiopathy; Factor H; Complement system; Medicine; Complement component 5; Immunology; Alternative complement pathway; Complement factor I; Complement factor B; Internal medicine; Antibody; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001100911,0.0004379423,0.0006755934,0.0001932796,0.0002849997,0.00003723151,0.0002539941,0.0001034685,0.001925093],"category_scores_gemma":[0.00003460239,0.000296268,0.0001210912,0.0001589733,0.0001245119,0.0001576478,0.00009064841,0.00009525377,0.0001363348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003265717,"about_ca_system_score_gemma":0.0001163038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001508374,"about_ca_topic_score_gemma":0.0006748035,"domain_scores_codex":[0.9975562,0.000292217,0.0006450448,0.0005522642,0.0001344314,0.0008198471],"domain_scores_gemma":[0.9987363,0.0002739084,0.0002404424,0.0005171329,0.0001167663,0.000115457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003143591,0.008173953,0.9818909,0.0001519747,0.001412849,0.0000128388,0.002344587,0.000005741286,0.001237215,0.00005871091,0.00031015,0.001257455],"study_design_scores_gemma":[0.02878504,0.004926838,0.9596786,0.0001537371,0.0007369972,0.000069419,0.0004815703,0.00002138541,0.003645515,0.000017962,0.001040782,0.0004420924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909438,0.0002638572,0.0003313231,0.00003353643,0.0003077505,0.006231705,0.001783438,0.00009102077,0.00001355582],"genre_scores_gemma":[0.9956585,0.000003408276,0.0007606322,0.00006618645,0.00003093159,0.00156733,0.001635839,0.00004993503,0.0002272269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02564145,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03609565215740576,"score_gpt":0.3038784670971199,"score_spread":0.2677828149397141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}