{"id":"W256521491","doi":"10.1038/mtna.2015.13","title":"Progress in RNAi-mediated Molecular Therapy of Acute and Chronic Myeloid Leukemia","year":2015,"lang":"en","type":"review","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; BC Cancer Agency; University of British Columbia; University of Alberta","funders":"","keywords":"RNA interference; Myeloid leukemia; Haematopoiesis; Leukemia; Cancer research; Progenitor cell; Genetic enhancement; Context (archaeology); Small interfering RNA; Myeloid; Biology; Stem cell; Immunology; Medicine; RNA; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004719448,0.0006173257,0.0007669082,0.001534861,0.0002302177,0.0005663742,0.0005889508,0.0006791076,0.001642263],"category_scores_gemma":[0.0003751617,0.0002244292,0.0003554556,0.001320035,0.0003931446,0.0008422008,0.0005225841,0.001528961,0.001113163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005068973,"about_ca_system_score_gemma":0.0006846696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006522114,"about_ca_topic_score_gemma":0.001072649,"domain_scores_codex":[0.9998533,0.00002455003,0.00001975399,0.00002706593,0.00005990534,0.0000154122],"domain_scores_gemma":[0.9998766,0.00005658198,0.00001891806,0.00000468864,0.00002984418,0.00001334205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005191647,0.0000929989,0.0001106417,0.01061169,0.0000605444,0.0001705125,0.00007425332,0.0005588583,0.009392709,0.008045245,0.01342729,0.9574033],"study_design_scores_gemma":[0.00001161646,0.0001343624,0.0005066329,0.0009707519,0.00006381455,0.0008910121,0.00002762939,0.0001378969,0.002796159,0.001655521,0.9927891,0.00001550815],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002574252,0.997644,0.0004735589,0.0001704943,0.0001511169,0.000006735544,0.000009577047,0.0000108357,0.00127612],"genre_scores_gemma":[0.00118089,0.9973828,0.0004452821,0.0001258202,0.00009579312,0.000008939716,0.00001990444,0.000001981073,0.0007385709],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001642263,"threshold_uncertainty_score":0.005493879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851746504359239,"score_gpt":0.2970700542225466,"score_spread":0.2785525891789543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}