{"id":"W2565239144","doi":"10.1158/1538-7445.am2015-2526","title":"Abstract 2526: Detection of Ara-CTP following exposure to CPX-351 and potentiation of action by fludarabine in leukemia cell lines using a bioluminescent bacterial biosensor","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Fludarabine; Cytarabine; Intracellular; Pharmacology; Chemistry; Biology; Leukemia; Biochemistry; Medicine; Immunology; Internal medicine; Cyclophosphamide; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002776707,0.0005944343,0.0004006672,0.0002252902,0.0001332363,0.0003196625,0.0004974816,0.0006818254,0.0009428086],"category_scores_gemma":[0.0002182622,0.0001634242,0.0002531634,0.00025586,0.0002429304,0.0002428961,0.0002306263,0.0006205616,0.0006539754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003651262,"about_ca_system_score_gemma":0.0001770771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008725442,"about_ca_topic_score_gemma":0.0005063086,"domain_scores_codex":[0.999638,0.00006883323,0.00002886407,0.00009304631,0.0001274611,0.00004378654],"domain_scores_gemma":[0.9998727,0.00003793977,0.00002682168,0.00001419079,0.00003114115,0.00001721775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003628988,0.00001202792,0.00005255911,0.0000180503,0.000001183941,0.00001018947,0.000009937009,0.00003189285,0.9994544,0.00002002692,0.00001264971,0.0003406121],"study_design_scores_gemma":[0.000003331518,0.0001065425,0.0008731312,0.00000307335,0.000003525915,0.00007506456,0.00001455626,0.0008219818,0.9977223,0.00001074085,0.0003620737,0.000003515839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671733,0.001669807,0.02789759,0.0001872843,0.00005291701,0.00006469409,0.0009590226,0.0003504555,0.001644932],"genre_scores_gemma":[0.9678506,0.001053235,0.02531761,0.00007699161,0.00001074771,0.00009914584,0.00181475,0.00003397607,0.003742931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009428086,"threshold_uncertainty_score":0.00315398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0814055769761631,"score_gpt":0.3756048735572448,"score_spread":0.2941992965810817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}