{"id":"W2565306870","doi":"10.1093/neuonc/now212.202","title":"DDIS-11. MOLECULAR MECHANISMS OF DIANHYDROGALACTITOL (VAL-083) IN OVERCOMING CHEMO-RESISTANCE IN GLIOBLASTOMA","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada); University of British Columbia","funders":"","keywords":"Temozolomide; Cancer research; DNA repair; Bevacizumab; Medicine; Cell cycle; DNA damage; Methyltransferase; Cancer; Glioma; Chemotherapy; Biology; Internal medicine; DNA; Methylation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722387,0.0005014844,0.0003639527,0.0003322842,0.0001807396,0.0003715342,0.000399965,0.0004455867,0.003048002],"category_scores_gemma":[0.00006313117,0.0001588068,0.0003630866,0.0002668516,0.0002080041,0.0002208031,0.0002268307,0.0007428919,0.0008130245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007162996,"about_ca_system_score_gemma":0.0003799191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009219465,"about_ca_topic_score_gemma":0.002168148,"domain_scores_codex":[0.9999249,0.00001190561,0.000006385407,0.0000133784,0.00001448844,0.00002877795],"domain_scores_gemma":[0.9999725,0.000002754234,0.000007070812,0.000002666626,0.00000430403,0.00001084751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004251527,0.001934699,0.001975066,0.002043931,0.0001235039,0.0008072412,0.000124956,0.003059027,0.749097,0.007750155,0.008061681,0.2207711],"study_design_scores_gemma":[0.00109642,0.01245237,0.01163291,0.0001810719,0.0001931287,0.002184108,0.00007391043,0.003940725,0.8446604,0.001795828,0.1217519,0.00003723882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7729019,0.1570981,0.00693247,0.003069964,0.000979069,0.001260243,0.004660836,0.0009850166,0.05211244],"genre_scores_gemma":[0.9298521,0.0444855,0.002550758,0.0006836397,0.0001076599,0.0003138912,0.002726749,0.00004378462,0.01923587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003048002,"threshold_uncertainty_score":0.01019657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008470725462263734,"score_gpt":0.2462153760054787,"score_spread":0.237744650543215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}