{"id":"W2565331052","doi":"10.1039/c6tb01401a","title":"Cellular internalization of rod-like nano hydroxyapatite particles and their size and dose-dependent effects on pre-osteoblasts","year":2016,"lang":"en","type":"article","venue":"Journal of Materials Chemistry B","topic":"Bone Tissue Engineering Materials","field":"Engineering","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Natural Science Foundation of China","keywords":"Intracellular; Extracellular; Internalization; Cell growth; Reactive oxygen species; Gene expression; Cytotoxicity; Cell; Biophysics; Cell culture; Particle size; Growth inhibition; Osteoblast; Cell biology; Chemistry; Molecular biology; Biology; In vitro; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002834251,0.0001787797,0.0003622503,0.00002822575,0.00001282903,0.00004356768,0.00009974447,0.00008702589,0.00008698692],"category_scores_gemma":[0.0001103492,0.000121086,0.00002882656,0.00002613146,0.0000305635,0.0001265729,0.00003967766,0.00004240881,0.000002255758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003516766,"about_ca_system_score_gemma":0.000007178473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001914876,"about_ca_topic_score_gemma":1.565758e-7,"domain_scores_codex":[0.9991139,0.0000344125,0.0004687714,0.0001023537,0.0001354151,0.0001451061],"domain_scores_gemma":[0.9993682,0.0001530177,0.0002121428,0.0001402885,0.00004073828,0.00008562962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009074853,0.00001408627,0.00005258269,0.000758554,0.00005915344,0.00001095293,0.0001631531,0.0002429255,0.9975216,0.00000368203,0.00003258464,0.001049925],"study_design_scores_gemma":[0.0007754453,0.00008779747,0.0007421889,0.0008459621,0.00002283853,0.0000659104,0.000006398011,0.00003724259,0.9970399,0.0001069209,0.00014335,0.000126005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980648,0.0003269643,0.0009616293,0.00002350478,0.0004661405,0.00007747034,0.0000200393,0.00003780303,0.00002161885],"genre_scores_gemma":[0.9993349,0.0001892856,0.000169656,0.000004684452,0.0002050257,0.000003672734,6.534324e-7,0.00003775609,0.00005439382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270042,"threshold_uncertainty_score":0.4937743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003322809649226771,"score_gpt":0.1745984950910799,"score_spread":0.1712756854418531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}