{"id":"W2565332355","doi":"10.1089/dna.2016.3507","title":"Expression of the Cardiac Maintenance and Survival Factor FGF-16 Gene Is Regulated by Csx/Nkx2.5 and Is an Early Target of Doxorubicin Cardiotoxicity","year":2016,"lang":"en","type":"article","venue":"DNA and Cell Biology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Research Manitoba","keywords":"Biology; Gene knockdown; Transcription factor; Molecular biology; Fibroblast growth factor; Small interfering RNA; Gene expression; Promoter; Doxorubicin; Transfection; Gene; Biochemistry; Genetics; Chemotherapy; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001531502,0.0001561977,0.0002874702,0.00002583293,0.00005338033,0.000006139289,0.0001456985,0.0002671114,0.00002079546],"category_scores_gemma":[0.00002972642,0.00008862794,0.00006512593,0.00004784489,0.0005050282,0.00000656857,0.0002392035,0.0000708348,3.743908e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007032036,"about_ca_system_score_gemma":0.00002690571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001356671,"about_ca_topic_score_gemma":0.000004335084,"domain_scores_codex":[0.9988173,0.0002396172,0.000191528,0.0004053648,0.00008932989,0.0002568749],"domain_scores_gemma":[0.9993334,0.00003425133,0.0001034071,0.0003491614,0.00007890979,0.0001009166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001181875,0.00001661812,0.1053309,0.00002778242,0.00002879355,1.94024e-7,0.00008996286,3.147581e-8,0.8933341,0.000004725417,0.0004551549,0.0005935832],"study_design_scores_gemma":[0.0005081106,0.0004278222,0.04594603,0.00001819901,0.000007716782,0.000001365371,0.00003001159,0.000001970058,0.9500926,0.00006395458,0.002787321,0.0001148776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971278,0.001410516,0.00007602133,0.0001116849,0.00006978241,0.0001766623,0.0009296688,0.000003507266,0.0000943773],"genre_scores_gemma":[0.9985451,0.00080008,0.00004963132,0.00003705128,0.00003587163,0.000004694302,0.00002822814,0.00001393435,0.0004853848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05938484,"threshold_uncertainty_score":0.3614143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007654900501127105,"score_gpt":0.2258356306141668,"score_spread":0.2181807301130397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}