{"id":"W2565341239","doi":"10.1016/j.etp.2016.12.007","title":"Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment","year":2016,"lang":"en","type":"article","venue":"Experimental and Toxicologic Pathology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Rotenone; Substantia nigra; Downregulation and upregulation; Parkinson's disease; Midbrain; Neuroscience; Pathology; Medicine; Biology; Cell biology; Central nervous system; Mitochondrion; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008845975,0.00015873,0.0002679024,0.00006022329,0.00005440182,0.000005595799,0.00005258976,0.0001148554,0.0001504054],"category_scores_gemma":[0.000008438177,0.00007358571,0.00005641365,0.00005992576,0.0001262958,0.00005948525,0.00002920537,0.00003734542,0.00000673752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007483376,"about_ca_system_score_gemma":0.00001332417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001522042,"about_ca_topic_score_gemma":0.000003637828,"domain_scores_codex":[0.9990698,0.0001374392,0.0002089572,0.0002749854,0.0001082828,0.0002006003],"domain_scores_gemma":[0.9996478,0.00003706574,0.00007490059,0.0001653813,0.00001028663,0.00006456228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000530236,0.001739103,0.01474273,0.000003464346,0.00001773035,0.0003427682,0.0005909342,1.280482e-7,0.9770901,0.000118638,0.00005015807,0.004774014],"study_design_scores_gemma":[0.004919279,0.003155705,0.0834504,0.00002142926,0.0000286571,0.0001835467,0.0003002047,0.00001523684,0.9072838,0.0002233869,0.0003265572,0.00009182272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977006,0.00116492,0.00008047382,0.0003314873,0.00005016446,0.0004512697,0.00005021089,0.00002040874,0.0001504891],"genre_scores_gemma":[0.9989752,0.0001299354,0.0004388268,0.0001294181,0.00002582115,0.0001114993,0.0000283581,0.000008800394,0.0001521055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06980632,"threshold_uncertainty_score":0.3000738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01840348222087194,"score_gpt":0.273142666968635,"score_spread":0.254739184747763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}