{"id":"W2565341239","doi":"10.1016/j.etp.2016.12.007","title":"Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment","year":2016,"lang":"en","type":"article","venue":"Experimental and Toxicologic Pathology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Rotenone; Substantia nigra; Downregulation and upregulation; Parkinson's disease; Midbrain; Neuroscience; Pathology; Medicine; Biology; Cell biology; Central nervous system; Mitochondrion; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003055979,0.001062948,0.001029702,0.001402582,0.0006713274,0.0007360006,0.0005438713,0.001341744,0.002200968],"category_scores_gemma":[0.0002194383,0.0005714878,0.0008803877,0.0005974242,0.001302339,0.0008793623,0.0004114496,0.00201315,0.0005948838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008405505,"about_ca_system_score_gemma":0.0007211757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003462986,"about_ca_topic_score_gemma":0.008075318,"domain_scores_codex":[0.9993805,0.00005185701,0.0000618248,0.0001630094,0.0001500932,0.0001926472],"domain_scores_gemma":[0.9996288,0.00002547304,0.0001420047,0.00004911556,0.00005009708,0.0001045258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009881539,0.0001753042,0.0001749131,0.00007099553,0.00002030105,0.0002014672,0.00006258192,0.00008028476,0.9967809,0.0001416005,0.00009766551,0.001205812],"study_design_scores_gemma":[0.0001402592,0.002061862,0.004548174,0.0000224942,0.00009066365,0.0004815916,0.0001727043,0.0008053471,0.9904532,0.0001435478,0.001059516,0.00002052984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912492,0.00201411,0.002151762,0.0002956149,0.0001563012,0.000103804,0.0008231614,0.0004672451,0.002738736],"genre_scores_gemma":[0.9865176,0.001281192,0.002672427,0.00008782237,0.00004734129,0.0001776478,0.0005448893,0.00007172079,0.008599225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003462986,"threshold_uncertainty_score":0.007362962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01840348222087194,"score_gpt":0.273142666968635,"score_spread":0.254739184747763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}