{"id":"W2565415217","doi":"10.1007/s12192-016-0753-x","title":"Components of a mammalian protein disaggregation/refolding machine are targeted to nuclear speckles following thermal stress in differentiated human neuronal cells","year":2016,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Hsp70; Stress granule; RNA splicing; Heat shock protein; Cell biology; Protein aggregation; Biology; Chaperone (clinical); RNA-binding protein; Proteostasis; Protein folding; Heat shock; Neurodegeneration; RNA; Biochemistry; Translation (biology); Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608985,0.0001193753,0.0002608494,0.0001690159,0.000240442,0.0003915122,0.0001928182,0.0001693168,0.000944094],"category_scores_gemma":[0.0001721208,0.0002024027,0.0003321505,0.0001818462,0.0002315784,0.0002738681,0.0003612488,0.0004435743,0.0002905218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004918583,"about_ca_system_score_gemma":0.0002490249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002373596,"about_ca_topic_score_gemma":0.003250734,"domain_scores_codex":[0.9998906,0.00000871746,0.00001158961,0.00002472897,0.00002923368,0.00003525505],"domain_scores_gemma":[0.999854,0.0000198962,0.00003496386,0.00002122746,0.00003514841,0.00003484722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001448645,0.00001104359,0.0006723339,0.00001904993,0.000008303202,0.0001061422,0.00006915024,0.00004587268,0.9980358,0.0001361033,0.00003314986,0.000718087],"study_design_scores_gemma":[0.00001054614,0.00008573791,0.04636947,0.000005675359,0.00002179103,0.0003182598,0.000193669,0.000974801,0.9511181,0.000108849,0.0007863736,0.000006735845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965253,0.0006887758,0.001884882,0.00006046381,0.00001855376,0.000006260619,0.0002036532,0.00002050821,0.0005916306],"genre_scores_gemma":[0.9970863,0.0002795965,0.0007759585,0.00003534432,0.000004793907,0.00001292317,0.0004157966,0.00001906365,0.00137026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002373596,"threshold_uncertainty_score":0.004719496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01310128521418304,"score_gpt":0.2398444593803676,"score_spread":0.2267431741661846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}