{"id":"W2565418077","doi":"10.3389/fcell.2016.00148","title":"Differential Contribution of the Aryl-Hydrocarbon Receptor and Toll-Like Receptor Pathways to IL-8 Expression in Normal and Cystic Fibrosis Airway Epithelial Cells Exposed to Pseudomonas aeruginosa","year":2016,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Cystic Fibrosis Canada; McGill University Health Centre","keywords":"Pseudomonas aeruginosa; Aryl hydrocarbon receptor; Pyocyanin; Cystic fibrosis; Microbiology; Biofilm; Signal transduction; Biology; Receptor; Inflammation; Immune system; Cell biology; Toll-like receptor; Innate immune system; Immunology; Bacteria; Gene; Quorum sensing; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416751,0.0001718767,0.0002809174,0.0002598035,0.000174267,0.000323258,0.0001046193,0.0003300341,0.0008295734],"category_scores_gemma":[0.0002373409,0.0001243985,0.0001805268,0.0001466048,0.0002404651,0.0003366924,0.0002028794,0.0004285163,0.0001601478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00015835,"about_ca_system_score_gemma":0.0001321833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003871947,"about_ca_topic_score_gemma":0.0003656568,"domain_scores_codex":[0.9997255,0.00006653194,0.00002232578,0.00003420733,0.00006262903,0.00008879368],"domain_scores_gemma":[0.9998592,0.00003979661,0.00001587423,0.00001312468,0.0000337302,0.00003824966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003689869,0.00002119924,0.0006741617,0.00003907222,0.000002701594,0.0001134742,0.0000556657,0.00002058973,0.9980812,0.00002694848,0.00001741899,0.000578667],"study_design_scores_gemma":[0.00006758564,0.001407511,0.2122254,0.00002976627,0.00005155387,0.00121122,0.001233382,0.002565293,0.7777495,0.0002719115,0.003159971,0.0000268496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978129,0.001226193,0.0003790751,0.00006728571,0.00001531483,0.00001285298,0.0001349824,0.000006751026,0.0003446267],"genre_scores_gemma":[0.997738,0.0007043551,0.0004536041,0.0000551461,0.00001970474,0.00005701183,0.000186228,0.000002752258,0.0007832492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008295734,"threshold_uncertainty_score":0.002775192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006542013286359531,"score_gpt":0.2164383586856435,"score_spread":0.209896345399284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}