{"id":"W2565594973","doi":"10.1172/jci.insight.89073","title":"Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity","year":2016,"lang":"en","type":"article","venue":"JCI Insight","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Hospital for Special Surgery; Lupus Research Alliance; Stanford Bio-X; Dr. Ralph and Marian Falk Medical Research Trust; Bill and Melinda Gates Foundation; Scleroderma Research Foundation; Ben May Charitable Trust; Scleroderma Foundation","keywords":"Medicine; Internal medicine; Cohort; Confounding; Transcriptome; Connective tissue disease; Disease; Rheumatology; Oncology; Autoimmune disease; Gene; Gene expression; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781966,0.0002115312,0.0007854647,0.0005194936,0.00004679668,0.00001071307,0.0001451407,0.0002047895,0.0005600978],"category_scores_gemma":[0.0001807364,0.0001210128,0.0006748031,0.0009718136,0.0001998245,0.0001376201,0.00002356054,0.0001170372,0.00001216794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009942152,"about_ca_system_score_gemma":0.0001747838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001056466,"about_ca_topic_score_gemma":0.00001224125,"domain_scores_codex":[0.9980031,0.0001071476,0.0007608281,0.0003574546,0.0005798835,0.0001915897],"domain_scores_gemma":[0.9983615,0.0001336439,0.000279975,0.0004739865,0.000487718,0.0002631588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000837237,0.000737283,0.1357912,0.0006041988,0.004280703,0.00001458785,0.0006413552,0.0002517978,0.853861,0.0002464091,0.001164952,0.001569313],"study_design_scores_gemma":[0.002169918,0.00008778807,0.9545344,0.009540568,0.009840922,0.000006352591,0.0006280809,0.0009483616,0.02184843,0.00001636282,0.000129911,0.000248922],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856828,0.01181455,0.0007932392,0.0001963972,0.0002967572,0.0003744577,0.000563941,0.00005328906,0.0002245844],"genre_scores_gemma":[0.9967939,0.002168735,0.00008186592,0.00005728711,0.00006215277,0.00002911178,0.0001110719,0.00002048462,0.0006753984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8320125,"threshold_uncertainty_score":0.6132678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03283835211699014,"score_gpt":0.2400562968725225,"score_spread":0.2072179447555323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}