{"id":"W2565609098","doi":"10.1007/s12311-016-0838-1","title":"Selective Transgenic Expression of Mutant Ubiquitin in Purkinje Cell Stripes in the Cerebellum","year":2016,"lang":"en","type":"article","venue":"The Cerebellum","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Hersenstichting; Koninklijke Nederlandse Akademie van Wetenschappen; Mount Royal University","keywords":"Ubiquitin; Cell biology; Purkinje cell; Proteasome; Mutant; Cerebellum; Biology; Neuroprotection; Transgene; Frameshift mutation; Neurodegeneration; Ubiquitin ligase; Molecular biology; Chemistry; Mutation; Biochemistry; Neuroscience; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001807647,0.0005837749,0.0003518648,0.0006604956,0.0002582237,0.0004461344,0.000512906,0.0005111264,0.00155511],"category_scores_gemma":[0.000126191,0.000376509,0.000323879,0.0002941604,0.0005827983,0.0002891548,0.0003537538,0.0007267916,0.0006122919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006165469,"about_ca_system_score_gemma":0.0003819027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002357492,"about_ca_topic_score_gemma":0.004056626,"domain_scores_codex":[0.9997497,0.00001790901,0.00002836118,0.00008577039,0.00006731969,0.00005089035],"domain_scores_gemma":[0.9996728,0.00002616141,0.0001453909,0.00002910118,0.00002270859,0.0001038539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000447101,0.00001927062,0.0000948945,0.00001755824,0.00000610802,0.0001372232,0.00001903339,0.00008006197,0.9990118,0.0001416117,0.00003315043,0.0003946774],"study_design_scores_gemma":[0.00005827988,0.0002152203,0.004450331,0.00001410891,0.00005307663,0.0006859315,0.00005483829,0.001660448,0.990266,0.0001304054,0.002400269,0.0000110712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877691,0.00122552,0.007515693,0.0001671346,0.00008065549,0.00008153435,0.0009354358,0.0004952778,0.001729603],"genre_scores_gemma":[0.9864981,0.0009399347,0.004053478,0.00004867417,0.00001732427,0.0000659637,0.0007282753,0.0001358702,0.007512339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002357492,"threshold_uncertainty_score":0.005202353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113917449667317,"score_gpt":0.226539339350797,"score_spread":0.2151475943840653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}