{"id":"W2565609098","doi":"10.1007/s12311-016-0838-1","title":"Selective Transgenic Expression of Mutant Ubiquitin in Purkinje Cell Stripes in the Cerebellum","year":2016,"lang":"en","type":"article","venue":"The Cerebellum","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Hersenstichting; Koninklijke Nederlandse Akademie van Wetenschappen; Mount Royal University","keywords":"Ubiquitin; Cell biology; Purkinje cell; Proteasome; Mutant; Cerebellum; Biology; Neuroprotection; Transgene; Frameshift mutation; Neurodegeneration; Ubiquitin ligase; Molecular biology; Chemistry; Mutation; Biochemistry; Neuroscience; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000764701,0.0002029105,0.0002051084,0.00006375133,0.00006952536,0.0000119787,0.0006114288,0.00017684,0.00008615269],"category_scores_gemma":[0.0000584214,0.0001025494,0.0001152046,0.0002256737,0.0001681751,0.000006794004,0.00009368386,0.0001888775,0.00001475406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002399888,"about_ca_system_score_gemma":0.00009552357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009011688,"about_ca_topic_score_gemma":0.0003461852,"domain_scores_codex":[0.9982291,0.0004644934,0.000358128,0.0003475935,0.0002065321,0.0003940805],"domain_scores_gemma":[0.9991347,0.0001099525,0.0001364538,0.0005335422,0.00004457868,0.00004077177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001775445,0.000126868,0.001169085,0.00002903947,0.000007507507,0.000002230576,0.001285735,0.000009347577,0.9948401,0.00008560065,0.0003307217,0.001936206],"study_design_scores_gemma":[0.001129052,0.0002752344,0.002284693,0.00008654855,0.000009230995,0.000006182972,0.0006682568,0.000007684106,0.9906832,0.0007642176,0.003916114,0.0001696087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921841,0.0006327238,0.0002637311,0.000779583,0.00007352077,0.0005974477,0.00004996922,0.000008483783,0.005410458],"genre_scores_gemma":[0.9986769,0.0003137636,0.00004967538,0.0001842347,0.0001287611,0.00006905416,0.00001158521,0.00002378311,0.0005422716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006492788,"threshold_uncertainty_score":0.4181843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113917449667317,"score_gpt":0.226539339350797,"score_spread":0.2151475943840653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}