{"id":"W2565802226","doi":"10.1016/s1525-0016(16)34201-0","title":"592. A Comparison of Length on the Potency and Toxicity of Small Interfering and Short Hairpin RNAs Targeting a Highly Conserved Site in HIV-1 RNA Coding for the Gag Polyprotein","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Marmara Üniversitesi","keywords":"Small interfering RNA; Small hairpin RNA; Biology; RNA interference; RNA; Gene silencing; Base pair; Molecular biology; Trans-acting siRNA; Cell biology; Gene; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004541997,0.0001448661,0.0002139834,0.00003922499,0.00004885018,0.00001993307,0.0001786905,0.00008170957,0.000001264041],"category_scores_gemma":[0.00009754628,0.0000955034,0.00006803755,0.00005466896,0.0001155742,0.000003777284,0.00007979365,0.0001001083,2.298397e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000793656,"about_ca_system_score_gemma":0.00002864521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001554207,"about_ca_topic_score_gemma":0.00007834511,"domain_scores_codex":[0.999135,0.0001082725,0.000277734,0.0002250244,0.00009059461,0.0001634138],"domain_scores_gemma":[0.9994859,0.00005786659,0.0001025161,0.0002353335,0.0000797539,0.00003868089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005647812,0.00005542548,0.004084489,0.00001808122,0.00006930679,0.000001480652,0.0006426375,0.0001364244,0.9892001,0.00009877491,0.00006785105,0.005060655],"study_design_scores_gemma":[0.0006797215,0.0008411335,0.0009843607,0.00007531693,0.00001019592,0.000002206554,0.0006620353,0.003001082,0.9932404,0.00006892372,0.0003212714,0.0001133249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850171,0.00518243,0.008728119,0.0005166916,0.00003578008,0.0004379571,0.00001497553,0.000003750008,0.00006321161],"genre_scores_gemma":[0.9988824,0.0003358309,0.0004080136,0.0002641731,0.00002379045,0.0000365561,0.00001191099,0.00001540082,0.00002197377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01386526,"threshold_uncertainty_score":0.3894516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05072966784146462,"score_gpt":0.2809932867766948,"score_spread":0.2302636189352301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}