{"id":"W2565802226","doi":"10.1016/s1525-0016(16)34201-0","title":"592. A Comparison of Length on the Potency and Toxicity of Small Interfering and Short Hairpin RNAs Targeting a Highly Conserved Site in HIV-1 RNA Coding for the Gag Polyprotein","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Marmara Üniversitesi","keywords":"Small interfering RNA; Small hairpin RNA; Biology; RNA interference; RNA; Gene silencing; Base pair; Molecular biology; Trans-acting siRNA; Cell biology; Gene; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004844509,0.0003958255,0.0002979946,0.0003478306,0.0001716671,0.0002647392,0.0002146453,0.000424028,0.002780969],"category_scores_gemma":[0.0003491283,0.0001769558,0.0004260415,0.00022289,0.0001624576,0.000206724,0.0001403707,0.0003557619,0.0008885086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002723025,"about_ca_system_score_gemma":0.0001957697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007581005,"about_ca_topic_score_gemma":0.0007939886,"domain_scores_codex":[0.9994469,0.0001447738,0.00007532084,0.00005501308,0.0002320129,0.00004601501],"domain_scores_gemma":[0.9996543,0.000132978,0.00003983576,0.00003100395,0.0000977522,0.00004424404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000365815,0.00009486511,0.0002107548,0.00005881658,0.0000112739,0.00002878762,0.00001418188,0.0001209359,0.9956154,0.00007060601,0.00008497856,0.003323707],"study_design_scores_gemma":[0.00003207708,0.001883066,0.004014862,0.000009054808,0.00003345303,0.0001716688,0.00001444796,0.0008679329,0.9909985,0.00003336758,0.001931962,0.000009555269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761839,0.00510679,0.004113398,0.0001105275,0.0001637207,0.0001077944,0.001432799,0.00009086182,0.01269015],"genre_scores_gemma":[0.9673564,0.00462889,0.008990815,0.0002349086,0.00006388799,0.0001901829,0.007810279,0.00007041258,0.01065416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002780969,"threshold_uncertainty_score":0.009303272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05072966784146462,"score_gpt":0.2809932867766948,"score_spread":0.2302636189352301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}