{"id":"W2565896303","doi":"10.1182/blood.v104.11.591.591","title":"The ICOS:ICOSL Costimulatory Pathway Plays an Important Role in GVHD and Bone Marrow (BM) Graft Rejection.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CD28; T cell; CD8; Immunology; Blockade; Cytotoxic T cell; CD40; Graft-versus-host disease; T-cell receptor; IL-2 receptor; Bone marrow; Biology; Medicine; Cancer research; Immune system; Cell biology; Receptor; Stem cell; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005512,0.00072102,0.0001727848,0.0002659436,0.0001393912,0.0002985414,0.0001730266,0.0002711753,0.001952716],"category_scores_gemma":[0.00007460629,0.00009072701,0.0001749371,0.0001170195,0.0001987946,0.0002004476,0.0002310046,0.000599046,0.000425043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002359281,"about_ca_system_score_gemma":0.0001993074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001614759,"about_ca_topic_score_gemma":0.0002555049,"domain_scores_codex":[0.999855,0.00002484107,0.00001063768,0.00002404008,0.00003536414,0.00005003125],"domain_scores_gemma":[0.9998387,0.00001219832,0.00007784515,0.000008076944,0.000009783967,0.00005338145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140495,0.00004295266,0.0005309656,0.00004429305,0.000004848404,0.00006160481,0.000007193075,0.00006731429,0.9967098,0.0001733278,0.00007308193,0.00214421],"study_design_scores_gemma":[0.00004618657,0.001244616,0.01496315,0.00003765826,0.00006287746,0.001007165,0.00004259251,0.001191394,0.9734706,0.0001818379,0.007745097,0.000006897717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898762,0.003638312,0.002921244,0.0001109705,0.00005638261,0.00002853098,0.0002715204,0.00009079455,0.003005944],"genre_scores_gemma":[0.9953785,0.0008930354,0.001187431,0.00006327951,0.00003469707,0.00003414169,0.0003560601,0.00001821529,0.002034658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001952716,"threshold_uncertainty_score":0.006532431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008369153659625882,"score_gpt":0.2364513406650149,"score_spread":0.228082187005389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}