{"id":"W2565977099","doi":"10.1021/jacs.6b11327","title":"Structural and Biochemical Characterization of Organotin and Organolead Compounds Binding to the Organomercurial Lyase MerB Provide New Insights into Its Mechanism of Carbon–Metal Bond Cleavage","year":2016,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Marine Biology and Environmental Chemistry","field":"Engineering","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Division of Chemistry; National Institute of Biomedical Imaging and Bioengineering; National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Light Source; Ministry of Higher Education and Scientific Research; U.S. Department of Energy; National Science Foundation","keywords":"Chemistry; Cleavage (geology); Stereochemistry; Bond cleavage; Metal; Cleave; Binding site; Enzyme; Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227123,0.0003100685,0.0002703722,0.0001407147,0.0001400445,0.0002675642,0.0002647583,0.0004022234,0.001676431],"category_scores_gemma":[0.0001474141,0.00019645,0.000379913,0.0001492079,0.0001417687,0.0002158537,0.0001296234,0.0005050407,0.0005588575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004374991,"about_ca_system_score_gemma":0.0001484041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127823,"about_ca_topic_score_gemma":0.001338807,"domain_scores_codex":[0.9998586,0.00001516883,0.000009250914,0.00003695168,0.00004673843,0.00003317951],"domain_scores_gemma":[0.9998883,0.00001650268,0.0000342087,0.00001073329,0.00001574961,0.00003456048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000735013,0.0000168616,0.0001805507,0.0000150459,0.000003912795,0.00002729,0.000005898023,0.00005903867,0.9991547,0.00002987293,0.00001635012,0.0004169928],"study_design_scores_gemma":[0.000009836128,0.0001465399,0.009261587,0.000003370867,0.000005958862,0.0001702669,0.00002606346,0.001665432,0.9870302,0.00003104513,0.001643006,0.000006510621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929544,0.001258932,0.003468436,0.0001145268,0.00001088618,0.0000183349,0.0004912127,0.00007688353,0.001606298],"genre_scores_gemma":[0.9874678,0.0004866274,0.005465257,0.00007689525,0.000004923194,0.00002604325,0.001772337,0.00004545937,0.004654566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676431,"threshold_uncertainty_score":0.005608261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004570983765495235,"score_gpt":0.1825277565835883,"score_spread":0.1779567728180931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}